Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 757086..757719 Replicon chromosome
Accession NZ_AP014573
Organism Mycobacterium tuberculosis str. Kurono

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag KURONO_RS03460 Protein ID WP_003403365.1
Coordinates 757086..757469 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag KURONO_RS03465 Protein ID WP_003403368.1
Coordinates 757564..757719 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KURONO_RS03435 752378..752914 + 537 WP_003403341.1 50S ribosomal protein L10 -
KURONO_RS03440 752951..753343 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
KURONO_RS03445 753336..754031 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
KURONO_RS03450 754102..755607 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
KURONO_RS03455 755688..756698 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
KURONO_RS03460 757086..757469 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
KURONO_RS03465 757564..757719 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KURONO_RS03470 757795..758511 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
KURONO_RS03475 758787..759095 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
KURONO_RS03480 759082..759327 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
KURONO_RS03485 759437..759874 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
KURONO_RS03490 759871..760125 - 255 WP_003911263.1 antitoxin VapB7 -
KURONO_RS03495 760239..762602 + 2364 WP_003898547.1 arylsulfatase AtsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T30711 WP_003403365.1 NZ_AP014573:c757469-757086 [Mycobacterium tuberculosis str. Kurono]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T30711 NZ_AP014573:c757469-757086 [Mycobacterium tuberculosis str. Kurono]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT30711 WP_003403368.1 NZ_AP014573:c757719-757564 [Mycobacterium tuberculosis str. Kurono]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT30711 NZ_AP014573:c757719-757564 [Mycobacterium tuberculosis str. Kurono]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References