30697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 193617..194188 Replicon chromosome
Accession NZ_AP014571
Organism Streptococcus mutans LP13

Toxin (Protein)


Gene name mazF Uniprot ID Q8DW95
Locus tag SMUNUM_RS00985 Protein ID WP_002262989.1
Coordinates 193856..194188 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2J9QC51
Locus tag SMUNUM_RS00980 Protein ID WP_002264866.1
Coordinates 193617..193862 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMUNUM_RS00960 (SMNUM_0167) 189524..190381 + 858 WP_002282920.1 replication initiation factor family protein -
SMUNUM_RS00965 (SMNUM_0168) 190687..191868 + 1182 WP_002282919.1 MobV family relaxase -
SMUNUM_RS00970 (SMNUM_0169) 192035..192496 + 462 WP_002282918.1 hypothetical protein -
SMUNUM_RS00975 192662..192760 + 99 WP_002282917.1 type I toxin-antitoxin system Fst family toxin -
SMUNUM_RS00980 (SMNUM_0170) 193617..193862 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SMUNUM_RS00985 (SMNUM_0171) 193856..194188 + 333 WP_002262989.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SMUNUM_RS00990 (SMNUM_0172) 194386..195177 - 792 WP_002297219.1 nucleotidyltransferase domain-containing protein -
SMUNUM_RS00995 195342..195695 + 354 Protein_175 transposase family protein -
SMUNUM_RS01000 (SMNUM_0175) 195877..197097 + 1221 WP_002267692.1 PTS sugar transporter subunit IIC -
SMUNUM_RS01005 (SMNUM_0176) 197075..197923 + 849 WP_002265112.1 alpha/beta hydrolase -
SMUNUM_RS01010 (SMNUM_0177) 198065..198667 + 603 WP_002269739.1 NADPH-dependent FMN reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 195342..195470 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12640.50 Da        Isoelectric Point: 6.4634

>T30697 WP_002262989.1 NZ_AP014571:193856-194188 [Streptococcus mutans LP13]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIGIFAPISNTKRDYPFYVSLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T30697 NZ_AP014571:193856-194188 [Streptococcus mutans LP13]
ATGGTAACCATCAAGCAAGGGTCAATTATCAAAATTAACTTGGATCCCAAACAAGGACATGAACAAAAAGGGTATCGTCC
GTACATTTGTCTAAACCATAGTATCGTAACCAAGTATTCTAATATTGGTATTTTTGCGCCAATTAGCAATACCAAGCGTG
ATTACCCTTTTTATGTTTCCCTAGAAGGAACAGAATCCACAGGGAAAGTATTATTAGACCAACTGGTTACAATCGATTTT
AATGCTAGAGATTATCGTTATGTGGAGGATATTCAGGAAGACTTATTAGATGAACTTTTAGCTAGGGTCAAGGTGCTATT
TGAAAAAGGATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9255.55 Da        Isoelectric Point: 4.3021

>AT30697 WP_002264866.1 NZ_AP014571:193617-193862 [Streptococcus mutans LP13]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT30697 NZ_AP014571:193617-193862 [Streptococcus mutans LP13]
ATGCAACTAGTCATCAATAAATGGGGAAATAGCTCCGCTATTCGTTTGCCAAAACAATTGGTACAAGAATTACAATTACA
AACAAATGATGTCTTAGACTATAAGGTATCAGGGAATAAAATTATCCTAGAAAAAGTGAATAATGTCCCTGAATTAACTG
TAGAAGATCTGTTTAAAGATTATCAAGGTGAACCTGTCAATGTTACCCCAGTTCTATTTGAAAGTGTGGGAAATGAACAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8DW95

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9QC51

References