Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 4849..5381 Replicon plasmid pSMB1
Accession NZ_AP014570
Organism Serpentinomonas mccroryi strain B1

Toxin (Protein)


Gene name parE Uniprot ID A0A060NPW9
Locus tag SMCB_RS11970 Protein ID WP_029463533.1
Coordinates 4849..5136 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060NS61
Locus tag SMCB_RS11975 Protein ID WP_029463534.1
Coordinates 5133..5381 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMCB_RS11935 14..970 + 957 WP_082027494.1 replication initiator protein A -
SMCB_RS11940 967..1251 + 285 WP_029463527.1 hypothetical protein -
SMCB_RS11945 1831..2109 + 279 WP_029463528.1 BrnT family toxin -
SMCB_RS11950 2069..2389 + 321 WP_045538175.1 BrnA antitoxin family protein -
SMCB_RS11955 3003..3398 - 396 WP_029463530.1 type II toxin-antitoxin system VapC family toxin -
SMCB_RS11960 3395..3652 - 258 WP_029463531.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SMCB_RS11965 3839..4567 - 729 WP_034112471.1 DNA-binding protein -
SMCB_RS11970 4849..5136 - 288 WP_029463533.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMCB_RS11975 5133..5381 - 249 WP_029463534.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SMCB_RS11980 6967..7629 + 663 WP_029463535.1 hypothetical protein -
SMCB_RS11990 8674..9711 - 1038 Protein_10 transposase -
SMCB_RS13000 9712..9903 - 192 Protein_11 asparaginase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..16368 16368


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10812.08 Da        Isoelectric Point: 5.9543

>T30695 WP_029463533.1 NZ_AP014570:c5136-4849 [Serpentinomonas mccroryi]
VKAVAFSPAAQADIGEIWDYSADRWGPDQADNYIDAIRDACYALARGTKHGRPAEVLPDFQKYLCGSHVVYFLNYPDHLD
VIRVLHQRQDAERHL

Download         Length: 288 bp

>T30695 NZ_AP014570:c5136-4849 [Serpentinomonas mccroryi]
GTGAAGGCTGTTGCGTTCTCGCCAGCGGCGCAGGCCGACATTGGCGAAATTTGGGACTACAGCGCCGATAGGTGGGGGCC
AGACCAAGCCGACAACTACATCGATGCCATTCGGGATGCGTGCTATGCGCTGGCCCGAGGGACAAAGCACGGTCGCCCGG
CCGAGGTGTTGCCGGACTTCCAAAAGTACCTGTGCGGCTCGCACGTAGTCTATTTTCTGAATTACCCTGACCATCTGGAC
GTGATTCGAGTCCTGCATCAACGGCAGGACGCTGAGCGCCATCTTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8920.00 Da        Isoelectric Point: 9.9933

>AT30695 WP_029463534.1 NZ_AP014570:c5381-5133 [Serpentinomonas mccroryi]
MSRNTSVSLGTHFASFIDAQVQGGRYGSASDVVRAGLRLLEEHESKVKALQDALRAGLESGEPRAFDFEAFKARKRAGLQ
PQ

Download         Length: 249 bp

>AT30695 NZ_AP014570:c5381-5133 [Serpentinomonas mccroryi]
ATGAGCCGAAACACATCCGTATCCCTCGGGACGCACTTCGCCAGCTTCATCGATGCCCAGGTGCAAGGCGGGCGCTACGG
CTCGGCCAGCGATGTTGTCCGGGCAGGCTTGCGGCTGCTGGAAGAGCACGAATCCAAGGTGAAGGCGCTGCAAGATGCTC
TACGCGCTGGCCTTGAATCCGGCGAGCCGCGCGCGTTCGACTTCGAGGCCTTCAAGGCCCGTAAGCGTGCAGGGCTGCAG
CCGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NPW9

Antitoxin

Source ID Structure
AlphaFold DB A0A060NS61

References