Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1976825..1977356 Replicon chromosome
Accession NZ_AP014569
Organism Serpentinomonas mccroryi strain B1

Toxin (Protein)


Gene name relE Uniprot ID A0A060NQL9
Locus tag SMCB_RS09155 Protein ID WP_045536488.1
Coordinates 1977075..1977356 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A060NNC6
Locus tag SMCB_RS09150 Protein ID WP_045536486.1
Coordinates 1976825..1977088 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMCB_RS09100 1971855..1972265 + 411 WP_045536471.1 DUF2442 domain-containing protein -
SMCB_RS09105 1972661..1972939 + 279 WP_045536473.1 hypothetical protein -
SMCB_RS12745 1972936..1973073 + 138 WP_197539298.1 hypothetical protein -
SMCB_RS09110 1973215..1973496 + 282 WP_045536475.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
SMCB_RS09115 1973468..1973797 + 330 WP_045536477.1 type II toxin-antitoxin system YafQ family toxin -
SMCB_RS09120 1973863..1974315 - 453 WP_045536480.1 type II toxin-antitoxin system YhaV family toxin -
SMCB_RS09125 1974315..1974635 - 321 WP_045536482.1 type II toxin-antitoxin system PrlF family antitoxin -
SMCB_RS09130 1974847..1975062 + 216 WP_045536484.1 hypothetical protein -
SMCB_RS09135 1975144..1975449 + 306 WP_045537948.1 hypothetical protein -
SMCB_RS09140 1975446..1975913 + 468 WP_197539299.1 TM1812 family CRISPR-associated protein -
SMCB_RS09145 1976067..1976561 + 495 WP_052468484.1 DUF2442 domain-containing protein -
SMCB_RS09150 1976825..1977088 + 264 WP_045536486.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
SMCB_RS09155 1977075..1977356 + 282 WP_045536488.1 type II toxin-antitoxin system YafQ family toxin Toxin
SMCB_RS09160 1977652..1978221 + 570 WP_045537953.1 Uma2 family endonuclease -
SMCB_RS09165 1978191..1979135 - 945 WP_045536490.1 LysR family transcriptional regulator -
SMCB_RS09170 1979245..1979652 + 408 WP_045537955.1 DoxX family protein -
SMCB_RS09175 1979738..1980538 - 801 WP_045536498.1 imidazole glycerol phosphate synthase subunit HisF -
SMCB_RS09180 1980554..1981294 - 741 WP_045536500.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
SMCB_RS09185 1981410..1982087 - 678 WP_045536502.1 imidazole glycerol phosphate synthase subunit HisH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10864.42 Da        Isoelectric Point: 7.8471

>T30694 WP_045536488.1 NZ_AP014569:1977075-1977356 [Serpentinomonas mccroryi]
MRRIEHTGQFKRDYKREAKGRHRATLDSELMPVVKTLACDQPLEARYCDHALSGDWKDHRDCHVKPDLVLIYRKPDDEVL
QLVRIGSHSELGL

Download         Length: 282 bp

>T30694 NZ_AP014569:1977075-1977356 [Serpentinomonas mccroryi]
ATGCGCAGGATTGAGCACACCGGCCAGTTTAAGCGCGACTACAAGCGCGAGGCGAAAGGTCGGCACCGTGCGACGCTCGA
TTCCGAACTGATGCCTGTCGTGAAAACCCTAGCCTGCGATCAGCCGCTGGAGGCGCGCTACTGCGACCACGCTCTCAGTG
GCGACTGGAAAGACCACCGGGACTGTCACGTCAAGCCCGACTTGGTGTTGATCTACCGCAAGCCCGATGACGAAGTATTG
CAACTCGTGCGTATCGGCTCGCATAGCGAGCTTGGCCTTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9539.99 Da        Isoelectric Point: 5.0893

>AT30694 WP_045536486.1 NZ_AP014569:1976825-1977088 [Serpentinomonas mccroryi]
MSANAVVRARIDEHIKEEASTVLAAMGLTVSDAFRIMLTRVAREKALPFEPLVPNETTIVAMREARAGNLKSFDSVEALM
TDLHAQD

Download         Length: 264 bp

>AT30694 NZ_AP014569:1976825-1977088 [Serpentinomonas mccroryi]
ATGTCTGCAAACGCTGTGGTTCGTGCCCGTATCGACGAGCACATCAAGGAAGAGGCATCGACTGTGCTGGCGGCGATGGG
CCTGACCGTGTCCGATGCATTCCGCATCATGCTGACCCGCGTCGCCCGCGAGAAGGCGTTGCCGTTCGAGCCGCTGGTGC
CAAACGAAACCACTATTGTTGCCATGCGCGAGGCTCGCGCCGGCAACCTCAAGAGCTTCGATAGCGTCGAGGCACTGATG
ACGGACTTGCATGCGCAGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NQL9

Antitoxin

Source ID Structure
AlphaFold DB A0A060NNC6

References