Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1964806..1965286 Replicon chromosome
Accession NZ_AP014569
Organism Serpentinomonas mccroryi strain B1

Toxin (Protein)


Gene name pasB Uniprot ID A0A060NQK4
Locus tag SMCB_RS09060 Protein ID WP_045536455.1
Coordinates 1964806..1965078 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A060NWX4
Locus tag SMCB_RS09065 Protein ID WP_045536457.1
Coordinates 1965062..1965286 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMCB_RS09050 1961958..1963391 + 1434 WP_045536451.1 efflux transporter outer membrane subunit -
SMCB_RS09055 1963450..1964559 - 1110 WP_045536453.1 patatin-like phospholipase family protein -
SMCB_RS09060 1964806..1965078 - 273 WP_045536455.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMCB_RS09065 1965062..1965286 - 225 WP_045536457.1 TraY domain-containing protein Antitoxin
SMCB_RS09070 1965512..1965730 + 219 WP_045536459.1 hypothetical protein -
SMCB_RS09075 1965723..1966049 + 327 WP_045536461.1 XRE family transcriptional regulator -
SMCB_RS09080 1966567..1967178 + 612 WP_045536463.1 hypothetical protein -
SMCB_RS09085 1967252..1968226 + 975 WP_197539297.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
SMCB_RS12530 1968860..1969873 - 1014 WP_171820298.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Relaxosome protein TraY

(4-49)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10353.16 Da        Isoelectric Point: 10.2723

>T30693 WP_045536455.1 NZ_AP014569:c1965078-1964806 [Serpentinomonas mccroryi]
MAWKVELDPAAERELCRIDPQVARRILVFLHGRVAHLDDPRSIGKALKGSKLGVFWKYRVGDWRIIASIEDSALRILVVR
IGDRKEVCHH

Download         Length: 273 bp

>T30693 NZ_AP014569:c1965078-1964806 [Serpentinomonas mccroryi]
ATGGCATGGAAGGTTGAACTCGACCCCGCCGCCGAGCGCGAGCTTTGCAGAATCGACCCGCAGGTAGCGCGGCGCATCCT
TGTTTTTTTGCATGGGCGTGTCGCCCATCTCGACGACCCCCGCAGCATCGGCAAAGCCCTCAAGGGCTCCAAGCTGGGGG
TCTTTTGGAAGTACCGTGTCGGCGACTGGCGCATCATCGCCAGCATCGAGGACAGTGCTCTGCGCATCCTTGTGGTGCGC
ATCGGCGACCGCAAAGAGGTTTGCCACCACTGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8492.77 Da        Isoelectric Point: 4.8356

>AT30693 WP_045536457.1 NZ_AP014569:c1965286-1965062 [Serpentinomonas mccroryi]
MLAIRLPAEVESRLEALARATGRTKTFYAREAILEHLDDLEDLYLAEQRLIDIRSGKTQTVPLEEVMKRYGMEG

Download         Length: 225 bp

>AT30693 NZ_AP014569:c1965286-1965062 [Serpentinomonas mccroryi]
ATGCTTGCCATCCGACTACCCGCTGAGGTGGAAAGCCGCCTTGAAGCGCTGGCGCGAGCCACCGGCCGCACCAAGACCTT
CTACGCCCGCGAGGCCATCCTTGAGCACCTAGACGACCTCGAAGATTTGTACTTGGCCGAGCAACGCCTGATCGATATTC
GCTCAGGCAAAACCCAGACCGTGCCTCTCGAAGAAGTGATGAAGCGCTATGGCATGGAAGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NQK4

Antitoxin

Source ID Structure
AlphaFold DB A0A060NWX4

References