Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 1776117..1776718 Replicon chromosome
Accession NZ_AP014569
Organism Serpentinomonas mccroryi strain B1

Toxin (Protein)


Gene name PumA Uniprot ID A0A060NWI0
Locus tag SMCB_RS08185 Protein ID WP_045536205.1
Coordinates 1776117..1776413 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A060NYD6
Locus tag SMCB_RS08190 Protein ID WP_045536212.1
Coordinates 1776416..1776718 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMCB_RS08160 1772851..1773555 + 705 WP_045536194.1 succinate dehydrogenase iron-sulfur subunit -
SMCB_RS08165 1773574..1773864 + 291 WP_045536196.1 succinate dehydrogenase assembly factor 2 -
SMCB_RS08170 1773928..1775238 + 1311 WP_045536198.1 citrate synthase -
SMCB_RS08175 1775336..1775761 - 426 WP_197539295.1 putative toxin-antitoxin system toxin component, PIN family -
SMCB_RS08180 1775764..1775988 - 225 WP_045536203.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
SMCB_RS08185 1776117..1776413 + 297 WP_045536205.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SMCB_RS08190 1776416..1776718 + 303 WP_045536212.1 putative addiction module antidote protein Antitoxin
SMCB_RS08195 1776750..1777343 - 594 WP_052468467.1 C39 family peptidase -
SMCB_RS08200 1777638..1778222 - 585 WP_045537880.1 hypothetical protein -
SMCB_RS08205 1778569..1779129 - 561 WP_144400310.1 hypothetical protein -
SMCB_RS08210 1779281..1780273 - 993 WP_052468468.1 IS91 family transposase -
SMCB_RS12875 1780608..1781195 + 588 WP_171820295.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-95)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11194.77 Da        Isoelectric Point: 9.0272

>T30692 WP_045536205.1 NZ_AP014569:1776117-1776413 [Serpentinomonas mccroryi]
MIELKQTETFCKWFAKLRDERATTAISLRLARLAYGHTGDAEPVGNGVSELRIHYGPGYRVYFQRRGDTIYLLLCGGDKK
SQARDIKTALRLADEWSE

Download         Length: 297 bp

>T30692 NZ_AP014569:1776117-1776413 [Serpentinomonas mccroryi]
ATGATCGAGCTCAAGCAGACCGAAACCTTCTGCAAATGGTTTGCCAAGCTCCGGGATGAGCGGGCGACAACGGCCATTTC
CTTGCGCTTGGCGCGGCTGGCCTACGGACACACTGGCGACGCCGAGCCGGTAGGTAACGGTGTCAGCGAGCTTCGCATCC
ACTACGGCCCCGGCTACCGGGTGTATTTCCAACGGCGCGGTGACACGATCTACTTGCTGCTCTGCGGGGGTGACAAGAAA
TCGCAGGCCCGCGACATCAAGACTGCGCTGCGCCTAGCTGATGAATGGAGCGAGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10513.11 Da        Isoelectric Point: 9.8657

>AT30692 WP_045536212.1 NZ_AP014569:1776416-1776718 [Serpentinomonas mccroryi]
MSKKLTTFDPAEHLKSDQAIADFMAGALETNDPGFIAHALGIVARAKGMAQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPAAPAAVR

Download         Length: 303 bp

>AT30692 NZ_AP014569:1776416-1776718 [Serpentinomonas mccroryi]
ATGAGCAAAAAACTGACCACCTTCGACCCCGCCGAGCATCTGAAATCCGACCAGGCCATCGCCGACTTCATGGCCGGTGC
GCTCGAGACCAACGACCCCGGTTTCATCGCCCACGCGCTGGGCATCGTGGCCCGCGCCAAGGGTATGGCGCAGATCGCCA
GCCAGACCGGGCTGTCGCGCGAACAGCTCTACCGCTCGTTTAGCGCCGAAGGCAACCCGACGCTGCGCACGACGCTGGCC
GTGATGAAGGCGCTCGGCATTGAGCTGTCGGCAAAACCTGCCGCCCCTGCCGCCGTTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NWI0

Antitoxin

Source ID Structure
AlphaFold DB A0A060NYD6

References