Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1303304..1303940 Replicon chromosome
Accession NZ_AP014569
Organism Serpentinomonas mccroryi strain B1

Toxin (Protein)


Gene name vapC Uniprot ID A0A060NQ07
Locus tag SMCB_RS06000 Protein ID WP_045535760.1
Coordinates 1303304..1303705 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A060NLM2
Locus tag SMCB_RS06005 Protein ID WP_045537733.1
Coordinates 1303707..1303940 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMCB_RS05975 1298566..1299636 - 1071 WP_045535755.1 phenylalanine--tRNA ligase subunit alpha -
SMCB_RS05980 1299847..1300224 - 378 WP_045535756.1 50S ribosomal protein L20 -
SMCB_RS05985 1300252..1300455 - 204 WP_045535757.1 50S ribosomal protein L35 -
SMCB_RS05990 1300579..1301187 - 609 WP_082027267.1 translation initiation factor IF-3 -
SMCB_RS05995 1301233..1303140 - 1908 WP_045535759.1 threonine--tRNA ligase -
SMCB_RS06000 1303304..1303705 - 402 WP_045535760.1 type II toxin-antitoxin system VapC family toxin Toxin
SMCB_RS06005 1303707..1303940 - 234 WP_045537733.1 antitoxin Antitoxin
SMCB_RS06010 1304108..1305439 - 1332 WP_045535761.1 isocitrate lyase -
SMCB_RS06015 1305677..1306387 - 711 WP_045535762.1 sulfite exporter TauE/SafE family protein -
SMCB_RS06020 1306426..1307919 - 1494 WP_082027268.1 oxygen-independent coproporphyrinogen III oxidase -
SMCB_RS06025 1307955..1308674 + 720 WP_045535763.1 fumarate/nitrate reduction transcriptional regulator Fnr -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14669.95 Da        Isoelectric Point: 8.5535

>T30691 WP_045535760.1 NZ_AP014569:c1303705-1303304 [Serpentinomonas mccroryi]
MIRYLLDTNIVIYVIKRKPLSALELFNRHAGHMAISSITLAELLHGAEKSSRVAENLRVVEDFASRLDVLSYGPKAAGHY
GSIRAALERIGQPIGINDLHIAAHARSEGLTLVTNNLGEFSRVPALQMENWVV

Download         Length: 402 bp

>T30691 NZ_AP014569:c1303705-1303304 [Serpentinomonas mccroryi]
ATGATCCGCTACCTGCTCGACACCAACATTGTCATCTACGTCATCAAGCGCAAGCCTTTGTCTGCCTTGGAGCTGTTCAA
CCGCCACGCAGGCCACATGGCCATTTCCTCCATCACGCTGGCAGAGTTGCTGCATGGCGCCGAAAAAAGCAGCAGAGTGG
CTGAGAACCTGCGCGTGGTAGAAGACTTTGCCAGCCGCCTCGACGTCTTGTCCTATGGCCCCAAGGCTGCCGGGCATTAC
GGCAGCATCCGCGCCGCCTTGGAAAGAATCGGACAGCCTATAGGCATCAATGACCTGCACATTGCTGCGCATGCCCGAAG
TGAAGGCCTGACGCTGGTCACCAACAACCTCGGCGAATTCAGCCGAGTGCCTGCCTTGCAGATGGAAAACTGGGTGGTTT
GA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8688.76 Da        Isoelectric Point: 5.7906

>AT30691 WP_045537733.1 NZ_AP014569:c1303940-1303707 [Serpentinomonas mccroryi]
MSVASVFINNRTQAVRLPADMRLPDDVKRVHIRAVGRERVIAPLDGAWDSFFLNSPAVSEDFLSERASQQQSEREGF

Download         Length: 234 bp

>AT30691 NZ_AP014569:c1303940-1303707 [Serpentinomonas mccroryi]
ATGTCAGTCGCCTCCGTTTTCATCAACAACCGCACCCAAGCCGTGCGCCTGCCGGCCGATATGCGCCTGCCCGACGACGT
CAAGCGCGTCCATATTCGCGCTGTGGGGCGCGAGCGCGTGATTGCGCCGCTGGATGGTGCTTGGGACAGCTTTTTTCTCA
ACTCACCAGCCGTCAGCGAAGATTTTTTGAGCGAGCGTGCCAGCCAGCAGCAAAGCGAGCGCGAAGGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NQ07

Antitoxin

Source ID Structure
AlphaFold DB A0A060NLM2

References