30690

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 751068..752106 Replicon chromosome
Accession NZ_AP014569
Organism Serpentinomonas mccroryi strain B1

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A060NTT6
Locus tag SMCB_RS03560 Protein ID WP_045535122.1
Coordinates 751534..752106 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A060NMG0
Locus tag SMCB_RS03555 Protein ID WP_045537543.1
Coordinates 751068..751529 (+) Length 154 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMCB_RS03515 746198..746452 - 255 WP_045535108.1 hypothetical protein -
SMCB_RS03520 746449..747186 - 738 WP_045535109.1 hypothetical protein -
SMCB_RS03525 747183..747683 - 501 WP_045535111.1 hypothetical protein -
SMCB_RS03530 747680..748534 - 855 WP_045535113.1 P63C domain-containing protein -
SMCB_RS03535 748545..749174 - 630 WP_045535114.1 hypothetical protein -
SMCB_RS03540 749180..749992 - 813 WP_082027413.1 ATP-binding protein -
SMCB_RS03545 750082..750564 - 483 WP_045535118.1 hypothetical protein -
SMCB_RS03550 750576..750839 - 264 WP_045535120.1 DNA-binding protein -
SMCB_RS03555 751068..751529 + 462 WP_045537543.1 helix-turn-helix domain-containing protein Antitoxin
SMCB_RS03560 751534..752106 + 573 WP_045535122.1 PIN domain-containing protein Toxin
SMCB_RS03565 752126..754375 + 2250 WP_045535124.1 hypothetical protein -
SMCB_RS03570 754463..754654 + 192 WP_045535126.1 hypothetical protein -
SMCB_RS03575 754654..755106 + 453 WP_045535128.1 DUF2924 domain-containing protein -
SMCB_RS03580 755103..756512 + 1410 WP_045535129.1 recombinase family protein -
SMCB_RS03585 756512..756883 + 372 WP_045535131.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 713207..763344 50137


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

SinI-like, DNA-binding domain

(83-129)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21300.39 Da        Isoelectric Point: 6.2125

>T30690 WP_045535122.1 NZ_AP014569:751534-752106 [Serpentinomonas mccroryi]
MSSHFTVVYDACVLYPAPLRDLLMHLALSDLYRARWSDMIHDEWTRNVQANRPDLAPAQLSRTRQLMNAHVRDCLVSGFE
HLIPSIQLPDADDRHVVAAAIHAGASLIVTFNLKDFPVESLKPYNLAAQHPDDFIVDLLDLQPAGVLEAVASHRRSLRNP
PKTADEYLDTLLAQGLTQSVAVMRQWTVAM

Download         Length: 573 bp

>T30690 NZ_AP014569:751534-752106 [Serpentinomonas mccroryi]
ATGAGCTCGCATTTCACTGTCGTCTACGACGCATGCGTGCTGTATCCGGCACCCTTGCGCGACCTACTGATGCATCTGGC
CCTCTCGGATCTGTACCGGGCGCGCTGGAGCGACATGATCCACGACGAGTGGACTCGCAATGTCCAAGCCAATCGACCGG
ACTTGGCCCCAGCGCAGTTGAGCCGCACGCGGCAGTTGATGAATGCGCATGTGCGCGACTGCTTGGTCTCGGGGTTCGAG
CACCTCATTCCCTCAATCCAATTGCCCGATGCCGATGACCGCCATGTGGTGGCCGCAGCCATCCACGCAGGTGCCAGTCT
GATCGTGACCTTCAACCTCAAAGACTTTCCGGTCGAGTCGCTCAAGCCCTACAACCTTGCCGCGCAGCATCCGGATGATT
TCATCGTCGATCTGCTGGATTTGCAGCCTGCGGGCGTGCTTGAAGCAGTGGCGAGTCATCGGCGGTCACTCAGGAATCCA
CCCAAGACGGCAGACGAATATCTGGACACCTTGCTGGCGCAAGGTTTGACTCAATCGGTGGCGGTGATGCGCCAATGGAC
TGTGGCCATGTGA

Antitoxin


Download         Length: 154 a.a.        Molecular weight: 16934.36 Da        Isoelectric Point: 6.8842

>AT30690 WP_045537543.1 NZ_AP014569:751068-751529 [Serpentinomonas mccroryi]
VNAPAIPKTLPSEEDIALARESGRALSTVLQTRSETQQIDFHDDKGAVRAVRIPTSALRLLLEVLTEIGQGNAVSIIPIH
AELTTQDAADVLNVSRPFLVQLLEKGDMPFHKIGTHRRVRYQDVVAYKKRIDAERRKALDELAAQAQELGMGY

Download         Length: 462 bp

>AT30690 NZ_AP014569:751068-751529 [Serpentinomonas mccroryi]
GTGAACGCTCCCGCCATTCCCAAAACCCTGCCCTCTGAAGAGGACATCGCGCTCGCCCGGGAATCTGGCCGCGCGCTGTC
GACCGTGCTCCAGACCCGCTCTGAAACCCAACAGATCGACTTTCACGACGACAAAGGCGCGGTGCGTGCCGTGCGTATCC
CGACCTCGGCACTGCGCCTGCTGCTTGAAGTTCTGACCGAGATCGGCCAGGGCAATGCGGTATCGATCATCCCGATCCAT
GCCGAGCTGACGACCCAGGATGCGGCCGACGTGCTCAACGTTTCGCGCCCCTTCCTTGTCCAATTGCTGGAGAAAGGCGA
CATGCCATTCCACAAGATTGGCACCCATCGCCGCGTGCGCTACCAGGATGTCGTCGCCTACAAGAAACGCATTGATGCCG
AGCGTCGCAAGGCCTTGGATGAACTGGCTGCGCAGGCTCAGGAACTCGGCATGGGGTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NTT6

Antitoxin

Source ID Structure
AlphaFold DB A0A060NMG0

References