Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 509192..510225 Replicon chromosome
Accession NZ_AP014569
Organism Serpentinomonas mccroryi strain B1

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A060NLL9
Locus tag SMCB_RS02290 Protein ID WP_045534759.1
Coordinates 509653..510225 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A060NJX1
Locus tag SMCB_RS02285 Protein ID WP_045534757.1
Coordinates 509192..509656 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SMCB_RS02255 504329..504739 - 411 WP_045534746.1 biopolymer transporter ExbD -
SMCB_RS02260 504757..505518 - 762 WP_045534748.1 MotA/TolQ/ExbB proton channel family protein -
SMCB_RS02265 505528..506403 - 876 WP_082027407.1 energy transducer TonB -
SMCB_RS02270 506568..507533 - 966 WP_045534751.1 LysR family transcriptional regulator -
SMCB_RS02275 507719..508417 + 699 WP_045534753.1 pirin family protein -
SMCB_RS02280 508478..509038 + 561 WP_045534755.1 flavodoxin family protein -
SMCB_RS02285 509192..509656 + 465 WP_045534757.1 helix-turn-helix domain-containing protein Antitoxin
SMCB_RS02290 509653..510225 + 573 WP_045534759.1 PIN domain-containing protein Toxin
SMCB_RS12835 510250..510435 - 186 WP_045537439.1 hypothetical protein -
SMCB_RS02300 510578..514153 + 3576 WP_045534761.1 DNA polymerase III subunit alpha -
SMCB_RS02305 514191..514676 - 486 WP_082027177.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-114)

Antitoxin

Helix-turn-helix domain, group 17

(83-130)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21410.66 Da        Isoelectric Point: 6.4057

>T30684 WP_045534759.1 NZ_AP014569:509653-510225 [Serpentinomonas mccroryi]
MSSHFTVIYDACVLYPAPLRDLLMRLALTDRFRARWSNVIHDEWMRNLHKQRPELDPAALEKTRALMNASVRDSLVEGFE
HLIPAIDLPDPDDRHVVAAAIHSGAETIVTFNLKDFPLGVLQRHNLDAQHPDDFIVDLFDLHPASVLQALAEQRAALKKP
PKSADELLDILLKQGLTQTVSILKGWKGAF

Download         Length: 573 bp

>T30684 NZ_AP014569:509653-510225 [Serpentinomonas mccroryi]
ATGAGCTCGCACTTCACGGTCATTTACGACGCGTGCGTGCTCTACCCAGCGCCGCTGCGCGATCTGCTCATGCGGCTGGC
GCTCACCGACCGCTTTCGTGCGCGCTGGTCCAATGTCATCCACGACGAGTGGATGCGCAACCTGCACAAGCAACGCCCCG
AGCTCGACCCTGCCGCCCTAGAAAAAACACGCGCCCTGATGAACGCGAGCGTGCGCGACAGCCTAGTCGAAGGATTTGAG
CACCTGATCCCGGCCATCGACTTGCCCGATCCCGATGACCGGCATGTGGTGGCAGCGGCCATCCACAGCGGCGCTGAAAC
CATCGTCACCTTCAACCTGAAGGACTTTCCGCTGGGGGTGCTGCAACGCCACAACCTAGACGCCCAGCACCCAGACGACT
TCATCGTCGATCTGTTTGACCTTCACCCCGCATCGGTGTTGCAGGCCTTGGCCGAACAGCGCGCCGCCCTCAAAAAACCA
CCCAAGAGCGCCGACGAGTTGCTCGACATCCTGCTCAAGCAGGGGCTGACGCAAACCGTGTCGATTCTCAAGGGTTGGAA
GGGAGCTTTTTGA

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 17060.41 Da        Isoelectric Point: 5.9956

>AT30684 WP_045534757.1 NZ_AP014569:509192-509656 [Serpentinomonas mccroryi]
MTTTQLPQALPTAEEVALARESGRALSAYLQMRAQTQQIEIFDDQGAAHPVRVPMSALRLLVDVLTEIGEGNAVSIIPVH
AELTTQEAADVLNVSRPHLVKLLESRAIPFHKTGTHRRVRYQDVVAYKERIDAQRRQALDALAEQAQELGLGYE

Download         Length: 465 bp

>AT30684 NZ_AP014569:509192-509656 [Serpentinomonas mccroryi]
ATGACCACGACCCAACTGCCACAAGCGCTGCCCACAGCCGAAGAGGTGGCGCTGGCGCGCGAGAGCGGGCGCGCGCTGTC
AGCCTACCTGCAGATGCGCGCACAAACGCAGCAGATCGAGATTTTTGACGACCAAGGCGCGGCGCATCCCGTGCGCGTCC
CGATGTCGGCGCTGCGCCTGCTGGTGGATGTGCTGACCGAGATCGGTGAGGGCAACGCGGTCAGCATCATCCCGGTGCAT
GCCGAGCTGACCACCCAAGAGGCGGCGGATGTGCTCAACGTATCGCGCCCGCACCTAGTCAAACTGCTGGAAAGCCGGGC
GATCCCGTTTCACAAAACCGGCACCCATCGGCGCGTGCGCTACCAAGACGTGGTCGCCTACAAAGAGCGCATCGATGCCC
AGCGCCGCCAAGCCCTAGACGCGCTGGCCGAGCAAGCGCAGGAACTGGGCCTAGGTTACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NLL9

Antitoxin

Source ID Structure
AlphaFold DB A0A060NJX1

References