Detailed information of TA system TA030682

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RHH
• Location: 2418446..2419017
• Replicon: chromosome
• Accession: NZ_AP014568
• Organism: Serpentinomonas raichei strain A1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SRAA_RS11235
• Protein ID: WP_029462746.1
• Coordinates: 2418706..2419017 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A060NIU2
• Locus tag: SRAA_RS11230
• Protein ID: WP_029462747.1
• Coordinates: 2418446..2418718 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SRAA_RS11215	2413623..2414912	-	1290	WP_045532791.1	hypothetical protein	-
SRAA_RS11220	2414915..2416210	-	1296	WP_029462749.1	glutamate-5-semialdehyde dehydrogenase	-
SRAA_RS11225	2416282..2418219	+	1938	WP_171816040.1	Tar ligand binding domain-containing protein	-
SRAA_RS11230	2418446..2418718	+	273	WP_029462747.1	CopG family ribbon-helix-helix protein	Antitoxin
SRAA_RS11235	2418706..2419017	+	312	WP_029462746.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SRAA_RS11240	2419014..2419715	+	702	WP_045532792.1	fumarylacetoacetate hydrolase family protein	-
SRAA_RS11245	2419717..2421303	-	1587	WP_144318758.1	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	-
SRAA_RS11250	2421438..2421695	-	258	WP_029462743.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
SRAA_RS11255	2421830..2422705	+	876	WP_045476666.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	-
SRAA_RS11260	2422702..2423262	+	561	WP_029462741.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11515.14 Da
• Isoelectric Point: 5.7237

>T30682 WP_029462746.1 NZ_AP014568:2418706-2419017 [Serpentinomonas raichei]
VPQVIVTEGAAEGLERCRKFLAAKAPDAARRAGQAIERQFLLLETFPDIGRPFPDMPELRELVIAFGDSGYVALYRHESA
DDTVYVLAFRHQKEAGYLNQPKP

Nucleotide

• Length: 312 bp

>T30682 NZ_AP014568:2418706-2419017 [Serpentinomonas raichei]
GTGCCACAAGTAATTGTTACCGAGGGCGCAGCCGAAGGCTTGGAGCGATGCCGGAAGTTCCTCGCCGCCAAGGCCCCGGA
TGCCGCCAGGCGGGCCGGACAAGCCATAGAGCGGCAATTCCTGCTGTTGGAAACCTTCCCCGACATCGGTCGGCCGTTCC
CTGACATGCCCGAGCTGCGCGAGTTGGTGATTGCCTTCGGGGACTCCGGCTATGTGGCGCTGTATCGCCATGAGTCCGCC
GACGATACGGTGTATGTCTTGGCATTCCGGCACCAGAAAGAGGCGGGCTACTTAAACCAACCCAAACCATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10605.96 Da
• Isoelectric Point: 8.1081

>AT30682 WP_029462747.1 NZ_AP014568:2418446-2418718 [Serpentinomonas raichei]
MATSLKIDDTLKSRVHHLAGQRRRSPHWIMLEAIQQYVEREEASERFKQEALTSWAAYKETGRHLTGQEMRTWLNTWGTE
AERAVPECHK

Nucleotide

• Length: 273 bp

>AT30682 NZ_AP014568:2418446-2418718 [Serpentinomonas raichei]
ATGGCAACGTCTCTCAAGATTGACGACACACTGAAAAGTCGTGTCCACCATCTGGCCGGCCAGCGCCGCCGTTCGCCGCA
CTGGATCATGCTCGAAGCCATCCAACAATACGTCGAGCGCGAGGAAGCAAGCGAGCGTTTCAAGCAGGAAGCCTTGACCT
CTTGGGCGGCCTACAAAGAAACCGGCCGGCATCTCACCGGCCAAGAAATGCGCACCTGGTTGAACACCTGGGGCACCGAA
GCCGAAAGGGCGGTGCCTGAGTGCCACAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A060NIU2