Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2389483..2389916 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SRAA_RS11150 Protein ID WP_045532771.1
Coordinates 2389692..2389916 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SRAA_RS11145 Protein ID WP_045533817.1
Coordinates 2389483..2389692 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS11125 2384751..2386418 + 1668 WP_045532765.1 ABC transporter ATP-binding protein/permease -
SRAA_RS12110 2386442..2387824 - 1383 WP_171820244.1 S8 family serine peptidase -
SRAA_RS11135 2387931..2388443 + 513 WP_045532767.1 RNA polymerase sigma factor -
SRAA_RS12640 2388443..2389393 + 951 WP_045532769.1 hypothetical protein -
SRAA_RS11145 2389483..2389692 + 210 WP_045533817.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SRAA_RS11150 2389692..2389916 + 225 WP_045532771.1 type II toxin-antitoxin system HicA family toxin Toxin
SRAA_RS11155 2389971..2390999 - 1029 WP_045533819.1 threonylcarbamoyl-AMP synthase -
SRAA_RS11160 2391074..2392312 - 1239 WP_045532773.1 5-(carboxyamino)imidazole ribonucleotide synthase -
SRAA_RS11165 2392309..2392812 - 504 WP_045532774.1 5-(carboxyamino)imidazole ribonucleotide mutase -
SRAA_RS11170 2392973..2393917 + 945 WP_045532776.1 thioredoxin -
SRAA_RS11175 2393921..2394487 - 567 WP_082040046.1 copper chaperone PCu(A)C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(10-64)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8361.71 Da        Isoelectric Point: 10.9132

>T30680 WP_045532771.1 NZ_AP014568:2389692-2389916 [Serpentinomonas raichei]
MGSLPVLKPQEVVRHLERLGFAESRQKGSHKQFRHPDGRATTVPFHKGQDVSPVLLRKIAQDINVLVEELLGRL

Download         Length: 225 bp

>T30680 NZ_AP014568:2389692-2389916 [Serpentinomonas raichei]
ATGGGCAGTCTGCCCGTTTTGAAGCCGCAGGAAGTGGTTCGCCATCTCGAACGCTTGGGTTTCGCTGAGTCTAGGCAGAA
GGGCTCGCACAAGCAGTTCCGCCATCCCGACGGTCGTGCAACAACCGTCCCGTTTCACAAGGGCCAAGATGTTTCACCCG
TCTTGCTGCGCAAAATTGCGCAAGACATCAACGTATTGGTCGAAGAGTTGCTGGGTCGGCTATAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7429.41 Da        Isoelectric Point: 3.8099

>AT30680 WP_045533817.1 NZ_AP014568:2389483-2389692 [Serpentinomonas raichei]
MKTFTAIVEKCTETGLYVGYVPGFPGAHTQGTSLDELQQNLQEVVSMLLEDGEPVLDAQFVGTQQLAIA

Download         Length: 210 bp

>AT30680 NZ_AP014568:2389483-2389692 [Serpentinomonas raichei]
ATGAAAACCTTTACCGCCATAGTAGAAAAGTGTACCGAAACAGGGCTTTACGTCGGTTACGTGCCCGGGTTCCCGGGTGC
GCATACCCAAGGCACCTCACTGGATGAGTTGCAGCAGAACCTCCAAGAGGTTGTCTCCATGCTCTTGGAAGATGGCGAGC
CCGTGTTGGATGCACAGTTTGTGGGTACCCAGCAGCTTGCCATCGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References