Detailed information of TA system TA030680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2389483..2389916
• Replicon: chromosome
• Accession: NZ_AP014568
• Organism: Serpentinomonas raichei strain A1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SRAA_RS11150
• Protein ID: WP_045532771.1
• Coordinates: 2389692..2389916 (+)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SRAA_RS11145
• Protein ID: WP_045533817.1
• Coordinates: 2389483..2389692 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SRAA_RS11125	2384751..2386418	+	1668	WP_045532765.1	ABC transporter ATP-binding protein/permease	-
SRAA_RS12110	2386442..2387824	-	1383	WP_171820244.1	S8 family serine peptidase	-
SRAA_RS11135	2387931..2388443	+	513	WP_045532767.1	RNA polymerase sigma factor	-
SRAA_RS12640	2388443..2389393	+	951	WP_045532769.1	hypothetical protein	-
SRAA_RS11145	2389483..2389692	+	210	WP_045533817.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SRAA_RS11150	2389692..2389916	+	225	WP_045532771.1	type II toxin-antitoxin system HicA family toxin	Toxin
SRAA_RS11155	2389971..2390999	-	1029	WP_045533819.1	threonylcarbamoyl-AMP synthase	-
SRAA_RS11160	2391074..2392312	-	1239	WP_045532773.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
SRAA_RS11165	2392309..2392812	-	504	WP_045532774.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
SRAA_RS11170	2392973..2393917	+	945	WP_045532776.1	thioredoxin	-
SRAA_RS11175	2393921..2394487	-	567	WP_082040046.1	copper chaperone PCu(A)C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (10-64)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8361.71 Da
• Isoelectric Point: 10.9132

>T30680 WP_045532771.1 NZ_AP014568:2389692-2389916 [Serpentinomonas raichei]
MGSLPVLKPQEVVRHLERLGFAESRQKGSHKQFRHPDGRATTVPFHKGQDVSPVLLRKIAQDINVLVEELLGRL

Nucleotide

• Length: 225 bp

>T30680 NZ_AP014568:2389692-2389916 [Serpentinomonas raichei]
ATGGGCAGTCTGCCCGTTTTGAAGCCGCAGGAAGTGGTTCGCCATCTCGAACGCTTGGGTTTCGCTGAGTCTAGGCAGAA
GGGCTCGCACAAGCAGTTCCGCCATCCCGACGGTCGTGCAACAACCGTCCCGTTTCACAAGGGCCAAGATGTTTCACCCG
TCTTGCTGCGCAAAATTGCGCAAGACATCAACGTATTGGTCGAAGAGTTGCTGGGTCGGCTATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7429.41 Da
• Isoelectric Point: 3.8099

>AT30680 WP_045533817.1 NZ_AP014568:2389483-2389692 [Serpentinomonas raichei]
MKTFTAIVEKCTETGLYVGYVPGFPGAHTQGTSLDELQQNLQEVVSMLLEDGEPVLDAQFVGTQQLAIA

Nucleotide

• Length: 210 bp

>AT30680 NZ_AP014568:2389483-2389692 [Serpentinomonas raichei]
ATGAAAACCTTTACCGCCATAGTAGAAAAGTGTACCGAAACAGGGCTTTACGTCGGTTACGTGCCCGGGTTCCCGGGTGC
GCATACCCAAGGCACCTCACTGGATGAGTTGCAGCAGAACCTCCAAGAGGTTGTCTCCATGCTCTTGGAAGATGGCGAGC
CCGTGTTGGATGCACAGTTTGTGGGTACCCAGCAGCTTGCCATCGCCTAA