Detailed information of TA system TA030678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicA
• Location: 2349954..2350361
• Replicon: chromosome
• Accession: NZ_AP014568
• Organism: Serpentinomonas raichei strain A1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SRAA_RS12345
• Protein ID: WP_082040039.1
• Coordinates: 2350173..2350361 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A060NT06
• Locus tag: SRAA_RS10970
• Protein ID: WP_045532723.1
• Coordinates: 2349954..2350166 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SRAA_RS10950	2345202..2346188	-	987	WP_045533801.1	ParB/RepB/Spo0J family partition protein	-
SRAA_RS10955	2346245..2347018	-	774	WP_045532715.1	ParA family protein	-
SRAA_RS10960	2347224..2347880	-	657	WP_045532717.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
SRAA_RS10965	2347877..2349880	-	2004	WP_045532719.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG	-
SRAA_RS10970	2349954..2350166	-	213	WP_045532723.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SRAA_RS12345	2350173..2350361	-	189	WP_082040039.1	type II toxin-antitoxin system HicA family toxin	Toxin
SRAA_RS10975	2350383..2351270	-	888	WP_052467566.1	hypothetical protein	-
SRAA_RS10980	2351361..2352845	-	1485	WP_045532725.1	aldehyde dehydrogenase	-
SRAA_RS10985	2352864..2353703	-	840	WP_045532727.1	ABC transporter permease	-
SRAA_RS10990	2353725..2354621	-	897	WP_045533805.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-61)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6832.94 Da
• Isoelectric Point: 11.3427

>T30678 WP_082040039.1 NZ_AP014568:c2350361-2350173 [Serpentinomonas raichei]
MKVGEVLRLLQADGWRLVATRGSHRQYKHASKPGRVTVPGKPSDELAPGTLNSIRKQADLKL

Nucleotide

• Length: 189 bp

>T30678 NZ_AP014568:c2350361-2350173 [Serpentinomonas raichei]
ATGAAGGTCGGCGAGGTCCTGAGACTGCTCCAAGCAGATGGGTGGCGTCTGGTTGCGACTCGTGGAAGCCATCGCCAATA
CAAGCATGCCAGCAAGCCTGGTCGCGTCACTGTTCCCGGCAAACCGAGCGATGAGCTGGCACCCGGCACCCTGAACAGCA
TTCGCAAGCAGGCTGATTTGAAATTGTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7454.40 Da
• Isoelectric Point: 3.9484

>AT30678 WP_045532723.1 NZ_AP014568:c2350166-2349954 [Serpentinomonas raichei]
MRYAIVIEKAAANYSAYVPDLPGCVATGTTVAEVEAELREAIAFHLEGLREDGIAIPDGSSQVEYIEVVA

Nucleotide

• Length: 213 bp

>AT30678 NZ_AP014568:c2350166-2349954 [Serpentinomonas raichei]
ATGCGCTACGCCATCGTCATTGAAAAGGCCGCAGCCAACTACTCGGCTTATGTTCCCGATCTGCCGGGTTGCGTAGCCAC
GGGCACAACCGTCGCTGAAGTCGAAGCCGAGTTGCGCGAGGCAATCGCCTTTCACCTCGAAGGGCTGCGCGAAGACGGCA
TAGCCATTCCAGACGGTTCCAGCCAAGTTGAATACATCGAGGTTGTTGCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A060NT06