Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 1915805..1916214 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag SRAA_RS12320 Protein ID WP_082040000.1
Coordinates 1915805..1915993 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A060NJD0
Locus tag SRAA_RS08975 Protein ID WP_045533603.1
Coordinates 1915996..1916214 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS08955 1910939..1911793 - 855 WP_144318744.1 TatD family hydrolase -
SRAA_RS08960 1911870..1913555 - 1686 WP_045533601.1 choice-of-anchor I family protein -
SRAA_RS08965 1913669..1914853 - 1185 WP_045532235.1 acetyl-CoA C-acyltransferase family protein -
SRAA_RS08970 1914966..1915706 - 741 WP_045532236.1 2OG-Fe dioxygenase family protein -
SRAA_RS12320 1915805..1915993 + 189 WP_082040000.1 type II toxin-antitoxin system HicA family toxin Toxin
SRAA_RS08975 1915996..1916214 + 219 WP_045533603.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SRAA_RS08980 1916211..1916444 - 234 WP_045532242.1 hypothetical protein -
SRAA_RS08985 1916534..1916971 + 438 WP_029462964.1 hypothetical protein -
SRAA_RS08990 1917054..1918397 + 1344 WP_052467535.1 hypothetical protein -
SRAA_RS08995 1918400..1919932 + 1533 WP_082040001.1 copper oxidase -
SRAA_RS12610 1919992..1920798 + 807 WP_171820235.1 copper-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6794.89 Da        Isoelectric Point: 11.6952

>T30677 WP_082040000.1 NZ_AP014568:1915805-1915993 [Serpentinomonas raichei]
MKVSELLRVLEKNGRFLVRQRGSHRQFHHASKSGTVTVAGKPSIDVPPSTLSSVLKQAGLKE

Download         Length: 189 bp

>T30677 NZ_AP014568:1915805-1915993 [Serpentinomonas raichei]
ATGAAGGTTTCTGAATTGCTGCGTGTGCTTGAAAAAAACGGACGGTTCTTGGTGCGCCAGCGGGGTAGCCATCGCCAGTT
TCACCACGCGAGCAAATCGGGGACAGTTACCGTTGCGGGCAAACCCAGCATCGATGTGCCTCCTAGCACCTTGAGCAGTG
TGCTCAAACAGGCTGGCTTGAAGGAGTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7769.95 Da        Isoelectric Point: 4.1933

>AT30677 WP_045533603.1 NZ_AP014568:1915996-1916214 [Serpentinomonas raichei]
MRFLVVIEKGETSYGAFVPDLPGCIAVGETEEEAVSLIQEAIQFHLEGLQIEGQPIPRPASKSKLIEVAFAA

Download         Length: 219 bp

>AT30677 NZ_AP014568:1915996-1916214 [Serpentinomonas raichei]
ATGCGATTTTTGGTGGTAATCGAAAAAGGCGAAACCAGTTACGGCGCTTTCGTGCCCGATCTTCCGGGCTGCATCGCGGT
TGGAGAGACTGAGGAGGAGGCCGTCAGCCTGATTCAAGAGGCTATTCAGTTTCATTTGGAAGGTTTGCAAATCGAAGGTC
AGCCGATTCCACGGCCAGCATCCAAAAGCAAATTGATCGAGGTTGCTTTTGCCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A060NJD0

References