Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1255458..1256221 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name tacT Uniprot ID A0A060NIA4
Locus tag SRAA_RS05900 Protein ID WP_045531444.1
Coordinates 1255727..1256221 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A060NGU9
Locus tag SRAA_RS05895 Protein ID WP_045531443.1
Coordinates 1255458..1255730 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS05880 1250873..1252867 - 1995 WP_045531440.1 acetate--CoA ligase -
SRAA_RS05885 1253038..1254588 + 1551 WP_045531441.1 fumarate hydratase -
SRAA_RS05890 1254637..1255260 - 624 WP_045531442.1 hypothetical protein -
SRAA_RS05895 1255458..1255730 + 273 WP_045531443.1 DUF1778 domain-containing protein Antitoxin
SRAA_RS05900 1255727..1256221 + 495 WP_045531444.1 GNAT family N-acetyltransferase Toxin
SRAA_RS05905 1256339..1258021 + 1683 WP_045531445.1 site-specific DNA-methyltransferase -
SRAA_RS05910 1258018..1259091 + 1074 WP_045531446.1 virulence RhuM family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 17588.33 Da        Isoelectric Point: 10.0586

>T30673 WP_045531444.1 NZ_AP014568:1255727-1256221 [Serpentinomonas raichei]
MSLQLSAPQPLATAHRLDGFACGEATLDEWLKRRALSNQLGGASRTFVVADAAQCVFGYYAMAAGAVSHQAATSAVRRNM
PDPVPVMVLARLAVDHRAQGLKLGASLLQDAVHRAVAVSHNSGVRALLVHALHERAKTFYEHCGFQASPLHSMTLMLRLH
SVKA

Download         Length: 495 bp

>T30673 NZ_AP014568:1255727-1256221 [Serpentinomonas raichei]
ATGAGTTTGCAACTCAGTGCGCCGCAGCCACTGGCCACGGCCCATCGGCTGGATGGCTTTGCTTGTGGCGAAGCGACATT
GGACGAATGGCTCAAGCGCCGCGCTCTGTCCAACCAGTTGGGTGGAGCCAGCCGTACCTTCGTCGTGGCCGATGCCGCGC
AATGCGTATTCGGCTACTACGCGATGGCGGCGGGCGCGGTCTCGCACCAGGCCGCCACCAGCGCCGTGCGCCGCAACATG
CCAGATCCGGTTCCGGTGATGGTTCTGGCCCGACTGGCCGTTGACCATCGGGCCCAAGGCCTCAAGCTTGGAGCATCCTT
GCTGCAAGACGCCGTGCATCGGGCGGTGGCGGTTTCGCACAACTCCGGTGTTCGGGCCCTGCTGGTGCACGCCCTACACG
AGCGCGCCAAGACGTTCTACGAACACTGCGGTTTTCAGGCATCGCCGCTCCATTCGATGACGCTGATGTTGCGCTTGCAC
TCCGTCAAGGCTTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9755.21 Da        Isoelectric Point: 5.7684

>AT30673 WP_045531443.1 NZ_AP014568:1255458-1255730 [Serpentinomonas raichei]
MRDAAINLRALPEQRNLIDHAASLLGKSRSDFMLEAACDRAQAVVLDRVFFSLDADKFQQFTAMLDAPPGPNPGLERLMA
VKAPWGSGAA

Download         Length: 273 bp

>AT30673 NZ_AP014568:1255458-1255730 [Serpentinomonas raichei]
ATGCGTGACGCCGCCATCAACCTGCGGGCCCTGCCCGAACAGCGCAATCTGATCGATCACGCTGCCAGCCTGCTCGGCAA
GAGCCGTTCGGACTTCATGCTCGAAGCGGCCTGCGACCGCGCTCAGGCCGTGGTGCTGGATCGGGTCTTTTTCAGCCTCG
ATGCCGACAAGTTCCAGCAGTTCACGGCCATGCTCGATGCGCCCCCAGGCCCGAATCCCGGGCTGGAACGCCTCATGGCG
GTCAAGGCGCCTTGGGGCAGCGGCGCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NIA4

Antitoxin

Source ID Structure
AlphaFold DB A0A060NGU9

References