Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1178725..1179250 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name parE Uniprot ID A0A060NI66
Locus tag SRAA_RS05535 Protein ID WP_045531380.1
Coordinates 1178725..1179015 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A060NN58
Locus tag SRAA_RS05540 Protein ID WP_045531382.1
Coordinates 1179008..1179250 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS05525 1174032..1174856 + 825 WP_082039931.1 uroporphyrinogen-III C-methyltransferase -
SRAA_RS12630 1176607..1178601 - 1995 Protein_1097 class I SAM-dependent DNA methyltransferase -
SRAA_RS05535 1178725..1179015 - 291 WP_045531380.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SRAA_RS05540 1179008..1179250 - 243 WP_045531382.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SRAA_RS05550 1179584..1180609 - 1026 WP_045531383.1 heat-inducible transcriptional repressor HrcA -
SRAA_RS05555 1180676..1181566 + 891 WP_045531384.1 NAD kinase -
SRAA_RS05560 1181563..1183218 + 1656 WP_045531386.1 DNA repair protein RecN -
SRAA_RS05565 1183203..1184069 + 867 WP_082039932.1 RNase adapter RapZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-91)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11068.70 Da        Isoelectric Point: 6.3682

>T30672 WP_045531380.1 NZ_AP014568:c1179015-1178725 [Serpentinomonas raichei]
MGKPYRLSPLAEADLEEIWLYTLKHWSMKQADTYHHNLVAAFEGLAAGTKQGRPADVLPEFMKYLCGSHVVYFLDCSDHL
DVIRVLHQRQDAEMHL

Download         Length: 291 bp

>T30672 NZ_AP014568:c1179015-1178725 [Serpentinomonas raichei]
ATGGGTAAGCCCTACCGACTGTCTCCGCTGGCCGAGGCCGACCTTGAGGAAATCTGGCTCTACACGCTCAAACACTGGTC
GATGAAGCAGGCAGACACCTACCACCACAACCTTGTGGCTGCCTTTGAGGGATTGGCAGCGGGCACAAAGCAGGGCCGCC
CCGCTGATGTTTTGCCGGAATTCATGAAGTACCTGTGCGGCTCGCACGTGGTCTATTTTCTCGACTGCTCCGACCATCTG
GACGTGATTCGCGTGCTGCATCAACGACAGGATGCTGAGATGCACCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8614.55 Da        Isoelectric Point: 7.4037

>AT30672 WP_045531382.1 NZ_AP014568:c1179250-1179008 [Serpentinomonas raichei]
MSRNTSVSLGTHFTSFIDAQVQGGRYGSASDVVRAGLRLLEEHEAKVKALQDALNAGLESGEPRSFDSGAFLNRMHARHG

Download         Length: 243 bp

>AT30672 NZ_AP014568:c1179250-1179008 [Serpentinomonas raichei]
ATGAGCCGAAACACATCCGTATCCCTCGGTACGCACTTCACCAGCTTCATTGATGCCCAAGTGCAAGGCGGGCGCTATGG
CTCGGCCAGTGATGTGGTCCGGGCAGGGTTGCGGCTGCTGGAAGAGCACGAAGCCAAGGTGAAGGCGCTGCAAGATGCGC
TGAACGCTGGCCTTGAGTCCGGTGAACCACGCTCGTTCGATAGCGGAGCGTTCTTGAACCGAATGCACGCGCGGCATGGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NI66

Antitoxin

Source ID Structure
AlphaFold DB A0A060NN58

References