Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 521686..522306 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name PumA Uniprot ID A0A060NLK6
Locus tag SRAA_RS02545 Protein ID WP_045530759.1
Coordinates 522016..522306 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A060NH56
Locus tag SRAA_RS02540 Protein ID WP_045530758.1
Coordinates 521686..522006 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS02495 516768..517010 + 243 WP_045533140.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
SRAA_RS02500 517007..517270 + 264 WP_045530751.1 Txe/YoeB family addiction module toxin -
SRAA_RS02505 517336..517575 + 240 WP_045530752.1 DUF4160 domain-containing protein -
SRAA_RS02510 517547..517804 + 258 WP_045530753.1 DUF2442 domain-containing protein -
SRAA_RS02515 517916..518134 + 219 WP_082040072.1 type II toxin-antitoxin system RelE/ParE family toxin -
SRAA_RS02520 518097..518417 + 321 WP_045530755.1 DNA-binding transcriptional regulator -
SRAA_RS02525 518539..519990 - 1452 WP_052467456.1 O-antigen ligase family protein -
SRAA_RS02530 520079..520504 - 426 WP_045530756.1 pilin -
SRAA_RS02535 520717..521142 - 426 WP_045530757.1 pilin -
SRAA_RS12590 521433..521588 + 156 WP_171820213.1 hypothetical protein -
SRAA_RS02540 521686..522006 - 321 WP_045530758.1 putative addiction module antidote protein Antitoxin
SRAA_RS02545 522016..522306 - 291 WP_045530759.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SRAA_RS02550 522364..522588 - 225 WP_045530760.1 type II toxin-antitoxin system HicA family toxin -
SRAA_RS02555 522588..522797 - 210 WP_045530761.1 type II toxin-antitoxin system HicB family antitoxin -
SRAA_RS02560 523199..523486 - 288 WP_045530762.1 HigA family addiction module antidote protein -
SRAA_RS02565 523568..524008 + 441 WP_045530763.1 hypothetical protein -
SRAA_RS02570 524001..525332 + 1332 WP_045530764.1 hypothetical protein -
SRAA_RS02575 525393..526232 + 840 WP_082039864.1 CDP-diacylglycerol--serine O-phosphatidyltransferase -
SRAA_RS02580 526280..526579 + 300 WP_045530765.1 type II toxin-antitoxin system RelE/ParE family toxin -
SRAA_RS02585 526583..526870 + 288 WP_045530766.1 putative addiction module antidote protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 517547..526870 9323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10661.32 Da        Isoelectric Point: 10.1325

>T30667 WP_045530759.1 NZ_AP014568:c522306-522016 [Serpentinomonas raichei]
MIEVRQTLAYAEWYGGLRDRQAKARIDIRIRRLSLGNPGDVKPVGEGVSELRIDHGPGYRVYFVQQGAVLIVLLAGGDKS
SQDLDIRLAKTLAKQL

Download         Length: 291 bp

>T30667 NZ_AP014568:c522306-522016 [Serpentinomonas raichei]
ATGATCGAAGTCCGCCAGACCCTTGCTTACGCCGAGTGGTATGGCGGCCTGCGTGATCGGCAGGCCAAGGCGCGCATCGA
CATCCGCATTCGCCGCTTGTCTCTTGGAAATCCGGGAGATGTGAAACCTGTGGGCGAGGGCGTCTCGGAACTGCGCATCG
ATCATGGTCCGGGCTATCGGGTCTATTTTGTTCAGCAAGGCGCTGTGCTGATCGTACTCCTCGCAGGAGGCGACAAGTCG
TCGCAAGACCTAGACATCCGGCTGGCCAAGACCCTGGCCAAGCAACTTTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 10907.45 Da        Isoelectric Point: 5.6491

>AT30667 WP_045530758.1 NZ_AP014568:c522006-521686 [Serpentinomonas raichei]
MSKTITKPWDPAEYLNTQEDMAAYLEAALEAGDPALVAAALGDIAKAKGMSQIARDAGLGRESLYKALAPSGNPEFATVM
KVVSALGLQLHASPAGTRAGTLPHSA

Download         Length: 321 bp

>AT30667 NZ_AP014568:c522006-521686 [Serpentinomonas raichei]
ATGTCCAAGACCATCACCAAACCGTGGGATCCGGCTGAGTATCTCAACACCCAAGAAGACATGGCCGCTTACCTCGAAGC
AGCGCTCGAAGCGGGCGACCCGGCCCTTGTCGCCGCCGCACTCGGAGACATCGCAAAGGCCAAAGGCATGAGTCAGATCG
CACGCGATGCCGGCCTGGGGCGCGAAAGCCTCTACAAGGCACTGGCACCCAGTGGCAACCCAGAGTTCGCCACGGTCATG
AAGGTCGTGTCTGCCTTGGGGCTGCAGCTTCACGCTTCCCCGGCCGGCACCAGAGCGGGCACCCTGCCACACAGCGCCTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NLK6

Antitoxin

Source ID Structure
AlphaFold DB A0A060NH56

References