Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 389920..390406 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name pasB Uniprot ID A0A060NL67
Locus tag SRAA_RS01875 Protein ID WP_045530666.1
Coordinates 389920..390198 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A060NMT7
Locus tag SRAA_RS01880 Protein ID WP_045530667.1
Coordinates 390182..390406 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS01840 385059..385391 - 333 WP_197538516.1 type II toxin-antitoxin system RelE/ParE family toxin -
SRAA_RS01845 385520..385744 + 225 WP_082039846.1 hypothetical protein -
SRAA_RS01850 385856..386176 + 321 WP_045530660.1 transcriptional regulator -
SRAA_RS12570 386321..386986 - 666 WP_171820201.1 hypothetical protein -
SRAA_RS01865 387831..389063 + 1233 WP_045530664.1 IS110 family transposase -
SRAA_RS01870 389274..389606 - 333 WP_045533080.1 HigA family addiction module antidote protein -
SRAA_RS12575 389621..389704 - 84 WP_082040069.1 hypothetical protein -
SRAA_RS01875 389920..390198 - 279 WP_045530666.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SRAA_RS01880 390182..390406 - 225 WP_045530667.1 TraY domain-containing protein Antitoxin
SRAA_RS01885 390471..391916 - 1446 WP_045530668.1 type II secretion system ATPase GspE -
SRAA_RS01890 391913..394141 - 2229 WP_045533082.1 type II secretion system secretin GspD -
SRAA_RS01895 394147..394938 - 792 WP_045533084.1 type II secretion system protein N -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 381766..390406 8640
- flank IS/Tn - - 387831..389063 1232


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Relaxosome protein TraY

(4-48)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10570.30 Da        Isoelectric Point: 10.3588

>T30664 WP_045530666.1 NZ_AP014568:c390198-389920 [Serpentinomonas raichei]
MAYLIKIDGAAENDLSKLDKPVARRITAFLRERVALLDDPRSIGEPLKGSSLGAFWKYRVGDYRVISLIEDDALRILVIR
IGNRREVYQRRP

Download         Length: 279 bp

>T30664 NZ_AP014568:c390198-389920 [Serpentinomonas raichei]
TTGGCCTATCTGATTAAGATTGATGGTGCCGCTGAAAATGACTTGTCCAAGCTCGACAAACCAGTTGCCAGACGCATCAC
CGCATTTTTGCGTGAGCGCGTGGCGCTGCTGGATGATCCCCGCAGCATCGGAGAACCGCTCAAAGGCTCGAGCTTGGGTG
CGTTTTGGAAATACCGCGTCGGCGACTATCGAGTCATAAGCCTGATCGAAGACGATGCCCTGCGAATTTTGGTCATTCGT
ATCGGTAACAGGCGCGAGGTGTACCAGCGCCGCCCATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8469.54 Da        Isoelectric Point: 5.5644

>AT30664 WP_045530667.1 NZ_AP014568:c390406-390182 [Serpentinomonas raichei]
MLAIRLPEQIESRLSALAHATGRTKTYYAREAIIEHLDDLEDLYLAEHRLLQARAGRSEAHSIEEVERRLGLSD

Download         Length: 225 bp

>AT30664 NZ_AP014568:c390406-390182 [Serpentinomonas raichei]
ATGCTTGCCATACGACTACCCGAGCAAATCGAAAGCCGGCTGAGCGCGCTAGCGCACGCCACCGGACGGACCAAGACCTA
CTATGCACGTGAGGCGATCATCGAGCACTTGGACGATCTAGAGGATTTGTACTTGGCTGAGCACAGGCTGCTACAGGCCC
GCGCCGGACGCAGCGAGGCGCACTCAATCGAAGAAGTGGAGCGCCGCCTTGGCCTATCTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NL67

Antitoxin

Source ID Structure
AlphaFold DB A0A060NMT7

References