Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 329237..329895 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name vapC Uniprot ID A0A060NGR2
Locus tag SRAA_RS01520 Protein ID WP_045530590.1
Coordinates 329482..329895 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A060NFF1
Locus tag SRAA_RS01515 Protein ID WP_045530588.1
Coordinates 329237..329485 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS01480 324337..324633 - 297 WP_029462152.1 type II toxin-antitoxin system RelE/ParE family toxin -
SRAA_RS01485 324635..324829 - 195 WP_029462151.1 hypothetical protein -
SRAA_RS01490 324920..325987 - 1068 WP_045530579.1 histidinol-phosphate transaminase -
SRAA_RS01495 326172..326759 + 588 WP_045530581.1 imidazoleglycerol-phosphate dehydratase HisB -
SRAA_RS01500 326782..327477 + 696 WP_045530583.1 imidazole glycerol phosphate synthase subunit HisH -
SRAA_RS01505 327529..328269 + 741 WP_045530585.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
SRAA_RS01510 328290..329096 + 807 WP_045530586.1 imidazole glycerol phosphate synthase subunit HisF -
SRAA_RS01515 329237..329485 + 249 WP_045530588.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SRAA_RS01520 329482..329895 + 414 WP_045530590.1 type II toxin-antitoxin system VapC family toxin Toxin
SRAA_RS01525 330047..331165 - 1119 WP_045530592.1 Rpn family recombination-promoting nuclease/putative transposase -
SRAA_RS01530 331248..331547 - 300 WP_045530594.1 HigA family addiction module antidote protein -
SRAA_RS01535 331561..331842 - 282 WP_045530596.1 type II toxin-antitoxin system RelE/ParE family toxin -
SRAA_RS01540 332076..333155 + 1080 WP_171820207.1 porin -
SRAA_RS11980 333544..334557 + 1014 WP_171820208.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-60)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15290.70 Da        Isoelectric Point: 6.7277

>T30660 WP_045530590.1 NZ_AP014568:329482-329895 [Serpentinomonas raichei]
MSYLIDTHVLSELRRKLPNPGVVAWFLRRPPPTLHLSVLTLGEIRKGIEGVDDATRRQSLLDWLETDLPPFFTGRILSID
AAVADRWGRLVAAAGRPLPAIDSLLAATALEHDLVLVTRNTKDFFGLPVEIFNPWSN

Download         Length: 414 bp

>T30660 NZ_AP014568:329482-329895 [Serpentinomonas raichei]
TTGAGCTACCTGATCGACACCCATGTGCTGTCTGAGTTGCGGCGCAAGTTGCCCAACCCCGGCGTGGTGGCATGGTTCTT
GCGCCGACCGCCGCCCACCTTGCATCTATCCGTACTGACCCTTGGGGAAATCCGCAAGGGCATCGAGGGAGTTGATGACG
CGACACGCCGGCAGTCGTTGCTCGATTGGCTGGAAACCGATCTGCCCCCCTTCTTTACCGGGCGCATCCTGAGCATAGAC
GCAGCGGTTGCCGACCGCTGGGGGCGTTTGGTCGCTGCTGCCGGGCGACCACTGCCCGCCATCGACAGCCTGCTCGCAGC
CACTGCGCTGGAGCACGACTTGGTGCTGGTGACTCGCAACACCAAAGATTTCTTTGGCCTACCCGTAGAGATCTTCAACC
CCTGGTCGAACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9452.73 Da        Isoelectric Point: 7.2033

>AT30660 WP_045530588.1 NZ_AP014568:329237-329485 [Serpentinomonas raichei]
MHTWQMQEAKARMSEVVKRAQTQPQDITLHGKSVAVVISRETFNRLSQAQDSLVDFMRRSPLYGADDIVFERDPSLTREV
AF

Download         Length: 249 bp

>AT30660 NZ_AP014568:329237-329485 [Serpentinomonas raichei]
ATGCACACATGGCAAATGCAAGAGGCAAAGGCGCGAATGTCGGAAGTGGTCAAGCGCGCCCAGACGCAGCCCCAGGACAT
CACCTTGCACGGCAAGTCGGTGGCCGTGGTGATTTCGCGCGAGACCTTTAATCGCCTGTCACAGGCGCAGGATTCGCTGG
TGGATTTCATGCGCCGCTCGCCGCTCTACGGTGCCGACGACATCGTCTTCGAGCGCGACCCGAGCTTGACGCGCGAGGTG
GCCTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NGR2

Antitoxin

Source ID Structure
AlphaFold DB A0A060NFF1

References