Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 324337..324829 Replicon chromosome
Accession NZ_AP014568
Organism Serpentinomonas raichei strain A1

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A060NMK8
Locus tag SRAA_RS01480 Protein ID WP_029462152.1
Coordinates 324337..324633 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A060NHG1
Locus tag SRAA_RS01485 Protein ID WP_029462151.1
Coordinates 324635..324829 (-) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SRAA_RS12155 320989..321156 + 168 WP_197537852.1 DUF2256 domain-containing protein -
SRAA_RS01460 321216..322898 + 1683 WP_082039839.1 cryptochrome/photolyase family protein -
SRAA_RS01465 322915..323613 - 699 WP_045476214.1 SDR family NAD(P)-dependent oxidoreductase -
SRAA_RS01470 323645..323944 - 300 WP_029462154.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
SRAA_RS01475 323941..324231 - 291 WP_029462153.1 hypothetical protein -
SRAA_RS01480 324337..324633 - 297 WP_029462152.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SRAA_RS01485 324635..324829 - 195 WP_029462151.1 hypothetical protein Antitoxin
SRAA_RS01490 324920..325987 - 1068 WP_045530579.1 histidinol-phosphate transaminase -
SRAA_RS01495 326172..326759 + 588 WP_045530581.1 imidazoleglycerol-phosphate dehydratase HisB -
SRAA_RS01500 326782..327477 + 696 WP_045530583.1 imidazole glycerol phosphate synthase subunit HisH -
SRAA_RS01505 327529..328269 + 741 WP_045530585.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
SRAA_RS01510 328290..329096 + 807 WP_045530586.1 imidazole glycerol phosphate synthase subunit HisF -
SRAA_RS01515 329237..329485 + 249 WP_045530588.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11329.16 Da        Isoelectric Point: 10.2508

>T30659 WP_029462152.1 NZ_AP014568:c324633-324337 [Serpentinomonas raichei]
MLPIIWRTSARDDLAHILRYIAQANPQAARRMRHLLEESVLPLSQHPYLYRSSERVPGLRELVAHPNYLVLYRVAATRIE
VVNVVHARREFPAPPGLD

Download         Length: 297 bp

>T30659 NZ_AP014568:c324633-324337 [Serpentinomonas raichei]
TTGCTGCCTATCATCTGGCGGACTTCGGCCCGCGACGATCTGGCGCACATTCTGCGCTACATCGCCCAAGCCAACCCGCA
GGCGGCGCGGCGCATGAGGCACCTGCTGGAAGAATCTGTGCTACCCCTCTCGCAGCACCCCTACCTGTACCGCAGCAGCG
AGCGCGTGCCGGGGCTGCGCGAACTCGTAGCCCACCCCAATTACCTCGTGCTGTACCGGGTGGCCGCCACGCGCATCGAG
GTGGTGAACGTGGTGCATGCGCGGCGCGAGTTCCCGGCGCCGCCCGGGCTGGATTAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 6900.76 Da        Isoelectric Point: 3.8428

>AT30659 WP_029462151.1 NZ_AP014568:c324829-324635 [Serpentinomonas raichei]
MSVALSPLVSEFETAEQEASYTAWLQAKVAASLADPRPPIPHDEVMAEMDALIDAIQSEALRST

Download         Length: 195 bp

>AT30659 NZ_AP014568:c324829-324635 [Serpentinomonas raichei]
ATGAGTGTTGCCTTGTCCCCCTTGGTGTCGGAGTTCGAAACCGCCGAACAAGAAGCCAGCTACACCGCCTGGCTGCAAGC
CAAAGTGGCGGCCAGCTTGGCCGATCCGCGCCCGCCGATTCCGCATGATGAGGTGATGGCCGAAATGGATGCCCTCATCG
ACGCGATCCAAAGCGAAGCCCTGCGGAGCACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060NMK8

Antitoxin

Source ID Structure
AlphaFold DB A0A060NHG1

References