Detailed information of TA system TA030658

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parE_1-parD/RHH(antitoxin)
• Location: 323941..324633
• Replicon: chromosome
• Accession: NZ_AP014568
• Organism: Serpentinomonas raichei strain A1

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A060NMK8
• Locus tag: SRAA_RS01480
• Protein ID: WP_029462152.1
• Coordinates: 324337..324633 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A060NKZ1
• Locus tag: SRAA_RS01475
• Protein ID: WP_029462153.1
• Coordinates: 323941..324231 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SRAA_RS01455	319316..320974	+	1659	WP_045530576.1	deoxyribodipyrimidine photo-lyase	-
SRAA_RS12155	320989..321156	+	168	WP_197537852.1	DUF2256 domain-containing protein	-
SRAA_RS01460	321216..322898	+	1683	WP_082039839.1	cryptochrome/photolyase family protein	-
SRAA_RS01465	322915..323613	-	699	WP_045476214.1	SDR family NAD(P)-dependent oxidoreductase	-
SRAA_RS01470	323645..323944	-	300	WP_029462154.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
SRAA_RS01475	323941..324231	-	291	WP_029462153.1	hypothetical protein	Antitoxin
SRAA_RS01480	324337..324633	-	297	WP_029462152.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SRAA_RS01485	324635..324829	-	195	WP_029462151.1	hypothetical protein	-
SRAA_RS01490	324920..325987	-	1068	WP_045530579.1	histidinol-phosphate transaminase	-
SRAA_RS01495	326172..326759	+	588	WP_045530581.1	imidazoleglycerol-phosphate dehydratase HisB	-
SRAA_RS01500	326782..327477	+	696	WP_045530583.1	imidazole glycerol phosphate synthase subunit HisH	-
SRAA_RS01505	327529..328269	+	741	WP_045530585.1	1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase	-
SRAA_RS01510	328290..329096	+	807	WP_045530586.1	imidazole glycerol phosphate synthase subunit HisF	-
SRAA_RS01515	329237..329485	+	249	WP_045530588.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11329.16 Da
• Isoelectric Point: 10.2508

>T30658 WP_029462152.1 NZ_AP014568:c324633-324337 [Serpentinomonas raichei]
MLPIIWRTSARDDLAHILRYIAQANPQAARRMRHLLEESVLPLSQHPYLYRSSERVPGLRELVAHPNYLVLYRVAATRIE
VVNVVHARREFPAPPGLD

Nucleotide

• Length: 297 bp

>T30658 NZ_AP014568:c324633-324337 [Serpentinomonas raichei]
TTGCTGCCTATCATCTGGCGGACTTCGGCCCGCGACGATCTGGCGCACATTCTGCGCTACATCGCCCAAGCCAACCCGCA
GGCGGCGCGGCGCATGAGGCACCTGCTGGAAGAATCTGTGCTACCCCTCTCGCAGCACCCCTACCTGTACCGCAGCAGCG
AGCGCGTGCCGGGGCTGCGCGAACTCGTAGCCCACCCCAATTACCTCGTGCTGTACCGGGTGGCCGCCACGCGCATCGAG
GTGGTGAACGTGGTGCATGCGCGGCGCGAGTTCCCGGCGCCGCCCGGGCTGGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10689.82 Da
• Isoelectric Point: 4.8605

>AT30658 WP_029462153.1 NZ_AP014568:c324231-323941 [Serpentinomonas raichei]
MSEATFTFRVDEALKTEFSSAAKARDRSGAQLLRDFMREFVQQQQEAAARDAWFRQQVQIGLDSANAGHLVSAEEVEAEA
AAWREQTRRGLAGLTA

Nucleotide

• Length: 291 bp

>AT30658 NZ_AP014568:c324231-323941 [Serpentinomonas raichei]
ATGAGCGAAGCCACGTTTACTTTCCGTGTCGATGAGGCCCTGAAAACCGAGTTCAGCAGCGCCGCCAAAGCGCGTGACCG
CAGCGGTGCGCAGTTGCTGCGCGACTTCATGCGCGAATTCGTGCAGCAGCAACAAGAGGCGGCGGCGCGCGACGCTTGGT
TTAGGCAGCAGGTGCAGATCGGGCTGGATTCGGCCAATGCCGGCCATTTGGTTTCGGCCGAGGAGGTGGAGGCCGAAGCC
GCTGCTTGGCGCGAACAAACGCGGCGCGGACTCGCGGGCTTGACTGCATGA

Structures

Toxin

• AlphaFold DB: A0A060NMK8

Antitoxin

• AlphaFold DB: A0A060NKZ1