Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 372635..373182 Replicon chromosome
Accession NZ_AP014525
Organism Vibrio cholerae MS6

Toxin (Protein)


Gene name relE Uniprot ID C3LV30
Locus tag MS6_RS15395 Protein ID WP_000229318.1
Coordinates 372880..373182 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag MS6_RS15390 Protein ID WP_000861987.1
Coordinates 372635..372892 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MS6_RS19490 367788..367901 + 114 WP_001900214.1 hypothetical protein -
MS6_RS15335 367850..368131 + 282 WP_001894429.1 DUF1289 domain-containing protein -
MS6_RS15345 368389..368925 + 537 WP_000469482.1 GNAT family N-acetyltransferase -
MS6_RS15350 369052..369567 + 516 WP_001201509.1 lipocalin family protein -
MS6_RS15355 369717..370214 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
MS6_RS15360 370211..370483 - 273 WP_000246253.1 DUF1778 domain-containing protein -
MS6_RS19510 370876..371001 + 126 WP_001900195.1 DUF645 family protein -
MS6_RS20130 371017..371055 + 39 WP_106019118.1 hypothetical protein -
MS6_RS15375 371251..371697 + 447 WP_000006157.1 hypothetical protein -
MS6_RS15380 371845..372114 - 270 WP_000277238.1 type II toxin-antitoxin system YafQ family toxin -
MS6_RS15385 372107..372385 - 279 WP_001258569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
MS6_RS15390 372635..372892 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MS6_RS15395 372880..373182 + 303 WP_000229318.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MS6_RS19515 373471..373695 + 225 WP_001894423.1 DUF3709 domain-containing protein -
MS6_RS19520 374139..374258 + 120 WP_071919600.1 DUF645 family protein -
MS6_RS20145 374262..374315 + 54 Protein_369 DUF645 family protein -
MS6_RS15405 374917..375921 + 1005 WP_000964931.1 LD-carboxypeptidase -
MS6_RS15415 376696..376876 + 181 Protein_371 DUF645 family protein -
MS6_RS15420 377143..377430 + 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
MS6_RS15425 377441..377758 + 318 WP_001232701.1 HigA family addiction module antidote protein -
MS6_RS20395 377755..377865 + 111 WP_134814058.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island qnrVC4 - 297729..445581 147852
- inside Integron qnrVC4 - 302809..445205 142396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11751.69 Da        Isoelectric Point: 5.1972

>T30640 WP_000229318.1 NZ_AP014525:372880-373182 [Vibrio cholerae MS6]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRIPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T30640 NZ_AP014525:372880-373182 [Vibrio cholerae MS6]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACCTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCATCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAATCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT30640 WP_000861987.1 NZ_AP014525:372635-372892 [Vibrio cholerae MS6]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT30640 NZ_AP014525:372635-372892 [Vibrio cholerae MS6]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C3LV30

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References