Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 371845..372385 | Replicon | chromosome |
| Accession | NZ_AP014525 | ||
| Organism | Vibrio cholerae MS6 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A151JGK8 |
| Locus tag | MS6_RS15380 | Protein ID | WP_000277238.1 |
| Coordinates | 371845..372114 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KML3 |
| Locus tag | MS6_RS15385 | Protein ID | WP_001258569.1 |
| Coordinates | 372107..372385 (-) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MS6_RS15325 | 366859..367101 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MS6_RS15330 | 367345..367731 | + | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| MS6_RS19490 | 367788..367901 | + | 114 | WP_001900214.1 | hypothetical protein | - |
| MS6_RS15335 | 367850..368131 | + | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
| MS6_RS15345 | 368389..368925 | + | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
| MS6_RS15350 | 369052..369567 | + | 516 | WP_001201509.1 | lipocalin family protein | - |
| MS6_RS15355 | 369717..370214 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| MS6_RS15360 | 370211..370483 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| MS6_RS19510 | 370876..371001 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
| MS6_RS20130 | 371017..371055 | + | 39 | WP_106019118.1 | hypothetical protein | - |
| MS6_RS15375 | 371251..371697 | + | 447 | WP_000006157.1 | hypothetical protein | - |
| MS6_RS15380 | 371845..372114 | - | 270 | WP_000277238.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| MS6_RS15385 | 372107..372385 | - | 279 | WP_001258569.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MS6_RS15390 | 372635..372892 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| MS6_RS15395 | 372880..373182 | + | 303 | WP_000229318.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MS6_RS19515 | 373471..373695 | + | 225 | WP_001894423.1 | DUF3709 domain-containing protein | - |
| MS6_RS19520 | 374139..374258 | + | 120 | WP_071919600.1 | DUF645 family protein | - |
| MS6_RS20145 | 374262..374315 | + | 54 | Protein_369 | DUF645 family protein | - |
| MS6_RS15405 | 374917..375921 | + | 1005 | WP_000964931.1 | LD-carboxypeptidase | - |
| MS6_RS15415 | 376696..376876 | + | 181 | Protein_371 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 297729..445581 | 147852 | |
| - | inside | Integron | qnrVC4 | - | 302809..445205 | 142396 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10406.11 Da Isoelectric Point: 9.5084
>T30639 WP_000277238.1 NZ_AP014525:c372114-371845 [Vibrio cholerae MS6]
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
MYKLEYSTQFKKDFKKITKMPISDIIEVGNVISKLQRGEKLEPKNVDHPLTGNWVGFRDCHIKPDLVLIYRVFNDQLQLA
RIGSHSDLF
Download Length: 270 bp
>T30639 NZ_AP014525:c372114-371845 [Vibrio cholerae MS6]
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA
ATGTATAAACTCGAATACTCCACACAGTTTAAGAAAGATTTCAAAAAGATAACTAAGATGCCGATTTCAGACATCATTGA
AGTCGGCAATGTTATTTCTAAGCTGCAACGCGGCGAAAAGCTTGAACCCAAGAATGTTGACCATCCGTTAACTGGAAATT
GGGTTGGATTTCGAGACTGCCACATTAAACCCGACCTAGTGTTAATCTATCGAGTTTTTAACGATCAACTACAACTAGCG
CGCATTGGTTCACATAGTGATTTATTCTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10088.58 Da Isoelectric Point: 6.0728
>AT30639 WP_001258569.1 NZ_AP014525:c372385-372107 [Vibrio cholerae MS6]
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
MRTEMLSTRIDHDTKIAFTNVCDEMGLSTSQAIKLFAKAVINHGGIPFELRVPQPNEVTASAIQELVEGKGHKAESVEAM
LNELTEGKVKHV
Download Length: 279 bp
>AT30639 NZ_AP014525:c372385-372107 [Vibrio cholerae MS6]
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA
ATGAGAACAGAAATGCTGAGCACGCGCATTGACCACGACACGAAAATTGCGTTCACAAACGTCTGCGATGAGATGGGTCT
AAGTACATCACAGGCCATAAAGTTATTTGCAAAAGCGGTTATTAATCATGGTGGAATCCCTTTTGAGCTGCGAGTTCCAC
AGCCTAATGAGGTTACTGCATCTGCAATTCAAGAGCTCGTTGAAGGAAAAGGACATAAAGCTGAATCCGTTGAAGCTATG
CTGAATGAGCTTACTGAAGGCAAAGTTAAGCATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151JGK8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A151KTP9 |