Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 366523..367101 | Replicon | chromosome |
| Accession | NZ_AP014525 | ||
| Organism | Vibrio cholerae MS6 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | O68848 |
| Locus tag | MS6_RS15320 | Protein ID | WP_001180243.1 |
| Coordinates | 366523..366840 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7DCR7 |
| Locus tag | MS6_RS15325 | Protein ID | WP_000557292.1 |
| Coordinates | 366859..367101 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MS6_RS15295 | 361891..362376 | + | 486 | WP_000495104.1 | GNAT family N-acetyltransferase | - |
| MS6_RS19475 | 362652..362888 | + | 237 | WP_032469475.1 | DUF3709 domain-containing protein | - |
| MS6_RS15300 | 363190..363561 | + | 372 | WP_001008377.1 | hypothetical protein | - |
| MS6_RS19480 | 363801..364079 | + | 279 | WP_001889186.1 | DUF3709 domain-containing protein | - |
| MS6_RS15305 | 364358..365011 | + | 654 | WP_000895163.1 | hypothetical protein | - |
| MS6_RS19485 | 365040..365162 | + | 123 | WP_080314583.1 | DUF3265 domain-containing protein | - |
| MS6_RS15310 | 365169..365873 | + | 705 | WP_000087610.1 | HNH endonuclease | - |
| MS6_RS15315 | 366031..366369 | + | 339 | WP_000713853.1 | hypothetical protein | - |
| MS6_RS15320 | 366523..366840 | - | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MS6_RS15325 | 366859..367101 | - | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MS6_RS15330 | 367345..367731 | + | 387 | WP_001015867.1 | NUDIX hydrolase | - |
| MS6_RS19490 | 367788..367901 | + | 114 | WP_001900214.1 | hypothetical protein | - |
| MS6_RS15335 | 367850..368131 | + | 282 | WP_001894429.1 | DUF1289 domain-containing protein | - |
| MS6_RS15345 | 368389..368925 | + | 537 | WP_000469482.1 | GNAT family N-acetyltransferase | - |
| MS6_RS15350 | 369052..369567 | + | 516 | WP_001201509.1 | lipocalin family protein | - |
| MS6_RS15355 | 369717..370214 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| MS6_RS15360 | 370211..370483 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| MS6_RS19510 | 370876..371001 | + | 126 | WP_001900195.1 | DUF645 family protein | - |
| MS6_RS20130 | 371017..371055 | + | 39 | WP_106019118.1 | hypothetical protein | - |
| MS6_RS15375 | 371251..371697 | + | 447 | WP_000006157.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | qnrVC4 | - | 297729..445581 | 147852 | |
| - | inside | Integron | qnrVC4 | - | 302809..445205 | 142396 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12158.97 Da Isoelectric Point: 9.7495
>T30637 WP_001180243.1 NZ_AP014525:c366840-366523 [Vibrio cholerae MS6]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS
Download Length: 318 bp
>T30637 NZ_AP014525:c366840-366523 [Vibrio cholerae MS6]
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
ATGCAAAATAAACAATATAAGCTCAGCCAATTAGCCCAAGAGCACTTACTCAAGATTAAACACTACACCATTGAAAATTT
CGCTGAAGCGCAGTGGCAAAAATATAAGTCGACCTTGCTTTCAGGTTTCCAAACTCTTGCGGATAACCCAGGACTAGGAA
AAAGCTGTGAAGATATTTACCAAAATGGTTTTTACTTTCCAGTGGGGAAACACATGGCTTATTACACCAAAGAAGCAAAC
TTCATTCTCATTGTTGCGGTATTAGGGCAATCACAACTGCCCCAAAAGCATCTCAAACAGTCACGCTTTGTTTCTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8961.25 Da Isoelectric Point: 5.6630
>AT30637 WP_000557292.1 NZ_AP014525:c367101-366859 [Vibrio cholerae MS6]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL
Download Length: 243 bp
>AT30637 NZ_AP014525:c367101-366859 [Vibrio cholerae MS6]
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
ATGCACACACTAACAGCAAATGATGCTAAACGAAATTTTGGTGAACTTCTTCTAAGCGCACAACGCGAACCTGTCATCAT
CAGCAAAAACAGTAAGAATACTGTCGTTGTCATGTCCATTAAGGACTTTGAAGAACTTGAAGCAATGAAACTCGATTATC
TCAAACACTGCTTTGAGTCTGCTCAGAAAGACTTAGATAGTGGCAAAACCGTTGATGGTGCCACTTTTCTAAACACCCTT
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UJR8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q7DCR7 |