30632

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 939369..939993 Replicon chromosome
Accession NZ_AP014523
Organism Helicobacter pylori NY40

Toxin (Protein)


Gene name relE Uniprot ID A0A060PQX9
Locus tag NY40_RS04680 Protein ID WP_041050817.1
Coordinates 939369..939635 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A060Q0Q7
Locus tag NY40_RS04685 Protein ID WP_041050819.1
Coordinates 939616..939993 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NY40_RS04655 935103..935984 + 882 WP_041050812.1 polysaccharide deacetylase -
NY40_RS04660 936031..936375 + 345 WP_021176252.1 hypothetical protein -
NY40_RS04665 936375..937341 + 967 Protein_893 GTP-binding protein -
NY40_RS04670 937347..938492 - 1146 WP_041050815.1 YbfB/YjiJ family MFS transporter -
NY40_RS04675 938904..939170 - 267 WP_041050817.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
NY40_RS04680 939369..939635 - 267 WP_041050817.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
NY40_RS04685 939616..939993 - 378 WP_041050819.1 hypothetical protein Antitoxin
NY40_RS04690 940734..943033 - 2300 Protein_898 outer membrane beta-barrel protein -
NY40_RS04695 943292..944047 - 756 WP_041050821.1 HugZ family heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10380.25 Da        Isoelectric Point: 9.6286

>T30632 WP_041050817.1 NZ_AP014523:c939635-939369 [Helicobacter pylori NY40]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLDPRFQDHALKGKWKSFRECHIKSDILLVYLVKDDELILLR
LGSHSELF

Download         Length: 267 bp

>T30632 NZ_AP014523:c939635-939369 [Helicobacter pylori NY40]
GTGTTGAAGCTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTGCTTTTGAATGGGTTTGATGATAGCGTTTT
GAAGGAAGTCATTCTAACCTTAAGAAAAAAAGAACCGCTAGATCCACGATTTCAAGATCATGCCCTAAAAGGCAAGTGGA
AATCTTTTAGGGAATGCCATATTAAATCCGACATTTTGCTTGTGTATTTAGTGAAAGATGATGAGCTGATTTTGTTAAGG
TTAGGCAGTCATAGTGAGTTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14729.60 Da        Isoelectric Point: 7.8456

>AT30632 WP_041050819.1 NZ_AP014523:c939993-939616 [Helicobacter pylori NY40]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKKDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNIQTQQAMRDADNKETDLFVEDFSSYSNERKKALGVEAQS

Download         Length: 378 bp

>AT30632 NZ_AP014523:c939993-939616 [Helicobacter pylori NY40]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAGTTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAAGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTT
GGGCATGAAACCCCAAACATTCAAACGCAACAAGCCATGAGAGATGCGGATAACAAAGAAACAGATTTGTTCGTTGAGGA
TTTTTCTAGTTATAGCAATGAGAGAAAAAAGGCTTTAGGTGTTGAAGCTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060PQX9

Antitoxin

Source ID Structure
AlphaFold DB A0A060Q0Q7

References