Detailed information of TA system TA030629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2464525..2465144
• Replicon: chromosome
• Accession: NZ_AP014522
• Organism: Pseudomonas protegens Cab57

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A2J7U9Z9
• Locus tag: PPC_RS11160
• Protein ID: WP_041120604.1
• Coordinates: 2464962..2465144 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: PPC_RS11155
• Protein ID: WP_041117178.1
• Coordinates: 2464525..2464926 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PPC_RS11125	2459989..2460336	-	348	WP_015634975.1	metalloregulator ArsR/SmtB family transcription factor	-
PPC_RS11130	2460566..2461120	+	555	WP_041117170.1	hypothetical protein	-
PPC_RS11135	2461354..2461785	-	432	WP_011060488.1	carboxymuconolactone decarboxylase family protein	-
PPC_RS11140	2461814..2462434	-	621	WP_041117172.1	NAD(P)H-dependent oxidoreductase	-
PPC_RS11145	2462431..2462877	-	447	WP_041117174.1	GNAT family N-acetyltransferase	-
PPC_RS11150	2462965..2464368	+	1404	WP_041117176.1	PLP-dependent aminotransferase family protein	-
PPC_RS11155	2464525..2464926	-	402	WP_041117178.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PPC_RS11160	2464962..2465144	-	183	WP_041120604.1	type II toxin-antitoxin system HicA family toxin	Toxin
PPC_RS11165	2465837..2466355	+	519	WP_041117180.1	sugar O-acetyltransferase	-
PPC_RS11170	2466376..2467614	+	1239	WP_041117182.1	aspartate aminotransferase family protein	-
PPC_RS11175	2467667..2469379	+	1713	WP_041120605.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6885.09 Da
• Isoelectric Point: 11.2684

>T30629 WP_041120604.1 NZ_AP014522:c2465144-2464962 [Pseudomonas protegens Cab57]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAELI

Nucleotide

• Length: 183 bp

>T30629 NZ_AP014522:c2465144-2464962 [Pseudomonas protegens Cab57]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCTGGCTGGGTGCTGGAGCGAGTCACCGGAAGCCATCATCTGTT
CAAGCATCCTTACAGGCCCAACACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGTACGGTCAGGGCCATCA
GAAAACTGGCTGAACTGATCTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14624.70 Da
• Isoelectric Point: 5.5455

>AT30629 WP_041117178.1 NZ_AP014522:c2464926-2464525 [Pseudomonas protegens Cab57]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFETAYSAAIEIAHVMLEELVRAGHAIPLPSPTRKHRANPDFAGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Nucleotide

• Length: 402 bp

>AT30629 NZ_AP014522:c2464926-2464525 [Pseudomonas protegens Cab57]
GTGCAATATCCCATCTGCATCGAATGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCTGATATTCCCGGCGCAGT
CACCGCCGGCGACACCTTCGAAACCGCCTACAGCGCGGCCATCGAGATTGCCCACGTCATGCTCGAAGAGCTGGTCCGAG
CGGGGCACGCCATCCCCCTGCCCTCTCCCACCCGCAAGCACCGCGCCAACCCCGATTTCGCGGGCATGGGCTGGGGCATG
CTGGAGATCGACATCACGCCTTACCTGGGCAAGACCGAAAAGGTCAACGTGACCCTGCCGGGTTATGTCATCCAGCAAAT
CGACCGCTTTGTCCGCGAGCACAACATCAAGAGCCGTTCGTCCTTCCTGGCCGATGCCGCGCTGGAAAAGCTCGGACGCT
GA

Structures

Toxin

• AlphaFold DB: A0A2J7U9Z9