Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2464525..2465144 Replicon chromosome
Accession NZ_AP014522
Organism Pseudomonas protegens Cab57

Toxin (Protein)


Gene name hicA Uniprot ID A0A2J7U9Z9
Locus tag PPC_RS11160 Protein ID WP_041120604.1
Coordinates 2464962..2465144 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PPC_RS11155 Protein ID WP_041117178.1
Coordinates 2464525..2464926 (-) Length 134 a.a.

Genomic Context

PPC_RS11130PPC_RS11150PPC_RS11165PPC_RS11170PPC_RS11175PPC_RS11125PPC_RS11135PPC_RS11140PPC_RS11145PPC_RS11155PPC_RS11160
Location: 2460566..2461120 (555 bp)
Type: Others
Protein ID: WP_041117170.1
Location: 2462965..2464368 (1404 bp)
Type: Others
Protein ID: WP_041117176.1
Location: 2465837..2466355 (519 bp)
Type: Others
Protein ID: WP_041117180.1
Location: 2466376..2467614 (1239 bp)
Type: Others
Protein ID: WP_041117182.1
Location: 2467667..2469379 (1713 bp)
Type: Others
Protein ID: WP_041120605.1
Location: 2459989..2460336 (348 bp)
Type: Others
Protein ID: WP_015634975.1
Location: 2461354..2461785 (432 bp)
Type: Others
Protein ID: WP_011060488.1
Location: 2461814..2462434 (621 bp)
Type: Others
Protein ID: WP_041117172.1
Location: 2462431..2462877 (447 bp)
Type: Others
Protein ID: WP_041117174.1
Location: 2464525..2464926 (402 bp)
Type: Antitoxin
Protein ID: WP_041117178.1
Location: 2464962..2465144 (183 bp)
Type: Toxin
Protein ID: WP_041120604.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PPC_RS111252459989..2460336-348WP_015634975.1metalloregulator ArsR/SmtB family transcription factor-
PPC_RS111302460566..2461120+555WP_041117170.1hypothetical protein-
PPC_RS111352461354..2461785-432WP_011060488.1carboxymuconolactone decarboxylase family protein-
PPC_RS111402461814..2462434-621WP_041117172.1NAD(P)H-dependent oxidoreductase-
PPC_RS111452462431..2462877-447WP_041117174.1GNAT family N-acetyltransferase-
PPC_RS111502462965..2464368+1404WP_041117176.1PLP-dependent aminotransferase family protein-
PPC_RS111552464525..2464926-402WP_041117178.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
PPC_RS111602464962..2465144-183WP_041120604.1type II toxin-antitoxin system HicA family toxinToxin
PPC_RS111652465837..2466355+519WP_041117180.1sugar O-acetyltransferase-
PPC_RS111702466376..2467614+1239WP_041117182.1aspartate aminotransferase family protein-
PPC_RS111752467667..2469379+1713WP_041120605.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6885.09 Da        Isoelectric Point: 11.2684

>T30629 WP_041120604.1 NZ_AP014522:c2465144-2464962 [Pseudomonas protegens Cab57]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPNTVPVPHPKKDLPRGTVRAIRKLAELI

Download         Length: 183 bp

>T30629 NZ_AP014522:c2465144-2464962 [Pseudomonas protegens Cab57]
GTGCAAAGCAGACAGTTGATCAAGGAGCTTGAAGCCGCTGGCTGGGTGCTGGAGCGAGTCACCGGAAGCCATCATCTGTT
CAAGCATCCTTACAGGCCCAACACCGTTCCGGTGCCTCACCCGAAGAAGGATCTGCCACGGGGTACGGTCAGGGCCATCA
GAAAACTGGCTGAACTGATCTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14624.70 Da        Isoelectric Point: 5.5455

>AT30629 WP_041117178.1 NZ_AP014522:c2464926-2464525 [Pseudomonas protegens Cab57]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFETAYSAAIEIAHVMLEELVRAGHAIPLPSPTRKHRANPDFAGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVREHNIKSRSSFLADAALEKLGR

Download         Length: 402 bp

>AT30629 NZ_AP014522:c2464926-2464525 [Pseudomonas protegens Cab57]
GTGCAATATCCCATCTGCATCGAATGGGGCGACGAACACACCGCCACCGGCATCCAGATTCCTGATATTCCCGGCGCAGT
CACCGCCGGCGACACCTTCGAAACCGCCTACAGCGCGGCCATCGAGATTGCCCACGTCATGCTCGAAGAGCTGGTCCGAG
CGGGGCACGCCATCCCCCTGCCCTCTCCCACCCGCAAGCACCGCGCCAACCCCGATTTCGCGGGCATGGGCTGGGGCATG
CTGGAGATCGACATCACGCCTTACCTGGGCAAGACCGAAAAGGTCAACGTGACCCTGCCGGGTTATGTCATCCAGCAAAT
CGACCGCTTTGTCCGCGAGCACAACATCAAGAGCCGTTCGTCCTTCCTGGCCGATGCCGCGCTGGAAAAGCTCGGACGCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2J7U9Z9

Antitoxin

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Source
ID
Structure
No matching records found

References