Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YefM-YoeB
Location 2136998..2137500 Replicon chromosome
Accession NZ_AP014520
Organism Aggregatibacter actinomycetemcomitans NUM4039 strain NUM 4039

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AANUM_RS10565 Protein ID WP_060828994.1
Coordinates 2136998..2137249 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AANUM_RS10570 Protein ID WP_060828995.1
Coordinates 2137246..2137500 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AANUM_RS10545 (AANUM_2132) 2132304..2133497 - 1194 WP_060828990.1 hypothetical protein -
AANUM_RS10550 (AANUM_2133) 2133506..2134279 - 774 WP_252997294.1 glycosyltransferase family 25 protein -
AANUM_RS10555 (AANUM_2134) 2134413..2135936 + 1524 WP_060828992.1 polysaccharide biosynthesis protein -
AANUM_RS10560 (AANUM_2135) 2135933..2136889 + 957 WP_060828993.1 polysaccharide pyruvyl transferase family protein -
AANUM_RS10565 (AANUM_2136) 2136998..2137249 + 252 WP_060828994.1 type II toxin-antitoxin system prevent-host-death family antitoxin Toxin
AANUM_RS10570 (AANUM_2137) 2137246..2137500 + 255 WP_060828995.1 Txe/YoeB family addiction module toxin Antitoxin
AANUM_RS10575 (AANUM_2138) 2137513..2138271 + 759 WP_060828996.1 YdcF family protein -
AANUM_RS10580 (AANUM_2139) 2138430..2139257 + 828 WP_060828997.1 DNA ligase -
AANUM_RS10585 (AANUM_2140) 2139390..2141564 - 2175 WP_060828998.1 DNA helicase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(1-84)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9408.69 Da        Isoelectric Point: 5.0637

>T30625 WP_060828994.1 NZ_AP014520:2136998-2137249 [Aggregatibacter actinomycetemcomitans NUM4039]
MNVISYSAFRAELATTLDQVVADHSPIMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>T30625 NZ_AP014520:2136998-2137249 [Aggregatibacter actinomycetemcomitans NUM4039]
ATGAATGTAATAAGTTATTCTGCGTTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAAT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGAGAGCGTTTATTAGCCTCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10200.77 Da        Isoelectric Point: 9.7542

>AT30625 WP_060828995.1 NZ_AP014520:2137246-2137500 [Aggregatibacter actinomycetemcomitans NUM4039]
MILAWTKTAWEDYLYWQQVDKKTLLRINKLIQNITRAPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>AT30625 NZ_AP014520:2137246-2137500 [Aggregatibacter actinomycetemcomitans NUM4039]
ATGATTTTAGCTTGGACGAAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGTTGCGCAT
TAATAAACTTATCCAAAATATTACCAGAGCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References