30624

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 2091844..2092436 Replicon chromosome
Accession NZ_AP014520
Organism Aggregatibacter actinomycetemcomitans NUM4039 strain NUM 4039

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag AANUM_RS10350 Protein ID WP_005542431.1
Coordinates 2092137..2092436 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag AANUM_RS10345 Protein ID WP_005542432.1
Coordinates 2091844..2092140 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AANUM_RS10330 (AANUM_2088) 2087365..2089503 - 2139 WP_005542435.1 TonB-dependent siderophore receptor -
AANUM_RS10335 (AANUM_2089) 2089773..2091170 - 1398 WP_005542434.1 MATE family efflux transporter -
AANUM_RS10340 (AANUM_2090) 2091197..2091811 + 615 WP_005542433.1 riboflavin synthase -
AANUM_RS10345 (AANUM_2091) 2091844..2092140 - 297 WP_005542432.1 putative addiction module antidote protein Antitoxin
AANUM_RS10350 (AANUM_2092) 2092137..2092436 - 300 WP_005542431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AANUM_RS10355 (AANUM_2093) 2092604..2092906 + 303 WP_005542430.1 ribosome assembly RNA-binding protein YhbY -
AANUM_RS10360 (AANUM_2094) 2092980..2093456 - 477 WP_005542429.1 transcription elongation factor GreA -
AANUM_RS10365 (AANUM_2095) 2093616..2095058 + 1443 WP_060828970.1 serine-type D-Ala-D-Ala carboxypeptidase -
AANUM_RS10370 (AANUM_2096) 2095159..2095815 - 657 WP_005552874.1 GTP cyclohydrolase I FolE -
AANUM_RS10375 (AANUM_2097) 2095944..2097158 + 1215 WP_005542426.1 molybdopterin molybdotransferase MoeA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11407.47 Da        Isoelectric Point: 10.4825

>T30624 WP_005542431.1 NZ_AP014520:c2092436-2092137 [Aggregatibacter actinomycetemcomitans NUM4039]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T30624 NZ_AP014520:c2092436-2092137 [Aggregatibacter actinomycetemcomitans NUM4039]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCCAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGATAAA
TCCACTCAAGAGAAAGATATTAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10852.32 Da        Isoelectric Point: 4.3776

>AT30624 WP_005542432.1 NZ_AP014520:c2092140-2091844 [Aggregatibacter actinomycetemcomitans NUM4039]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT30624 NZ_AP014520:c2092140-2091844 [Aggregatibacter actinomycetemcomitans NUM4039]
ATGAGTGAACAATTGAAAAATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAGGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATTGCACGAGCCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTACGCTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References