Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1391645..1392195 Replicon chromosome
Accession NZ_AP014520
Organism Aggregatibacter actinomycetemcomitans NUM4039 strain NUM 4039

Toxin (Protein)


Gene name relE Uniprot ID G4A7B4
Locus tag AANUM_RS07015 Protein ID WP_005539226.1
Coordinates 1391645..1391911 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JQ67
Locus tag AANUM_RS07020 Protein ID WP_005539223.1
Coordinates 1391923..1392195 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AANUM_RS07000 (AANUM_1418) 1388105..1388518 + 414 WP_005539234.1 hydroxyisourate hydrolase -
AANUM_RS07005 (AANUM_1419) 1388711..1389622 + 912 WP_060828879.1 hypothetical protein -
AANUM_RS07010 (AANUM_1420) 1390054..1391613 - 1560 WP_005539229.1 glutamine-hydrolyzing GMP synthase -
AANUM_RS07015 (AANUM_1421) 1391645..1391911 - 267 WP_005539226.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
AANUM_RS07020 (AANUM_1422) 1391923..1392195 - 273 WP_005539223.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
AANUM_RS07025 (AANUM_1423) 1392450..1393802 - 1353 WP_005551801.1 anaerobic C4-dicarboxylate transporter DcuC -
AANUM_RS07030 (AANUM_1424) 1394178..1394351 - 174 WP_005552670.1 hypothetical protein -
AANUM_RS07035 (AANUM_1425) 1394479..1394682 + 204 WP_005544186.1 IS3 family transposase -
AANUM_RS07040 1394689..1394823 + 135 WP_005544187.1 hypothetical protein -
AANUM_RS07045 (AANUM_1426) 1395179..1395661 - 483 WP_005552667.1 redoxin family protein -
AANUM_RS07050 (AANUM_1427) 1395676..1396317 - 642 WP_005546457.1 cytochrome c biogenesis protein CcdA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10502.03 Da        Isoelectric Point: 7.2393

>T30620 WP_005539226.1 NZ_AP014520:c1391911-1391645 [Aggregatibacter actinomycetemcomitans NUM4039]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLVLIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

>T30620 NZ_AP014520:c1391911-1391645 [Aggregatibacter actinomycetemcomitans NUM4039]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCGTTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10147.52 Da        Isoelectric Point: 6.2633

>AT30620 WP_005539223.1 NZ_AP014520:c1392195-1391923 [Aggregatibacter actinomycetemcomitans NUM4039]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Download         Length: 273 bp

>AT30620 NZ_AP014520:c1392195-1391923 [Aggregatibacter actinomycetemcomitans NUM4039]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FY83

Antitoxin

Source ID Structure
AlphaFold DB X2JQ67

References