Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1358272..1358806 Replicon chromosome
Accession NZ_AP014520
Organism Aggregatibacter actinomycetemcomitans NUM4039 strain NUM 4039

Toxin (Protein)


Gene name relE Uniprot ID A0A142FYB7
Locus tag AANUM_RS06840 Protein ID WP_005540089.1
Coordinates 1358272..1358562 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5D0EPW1
Locus tag AANUM_RS06845 Protein ID WP_005540091.1
Coordinates 1358552..1358806 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AANUM_RS06815 (AANUM_1384) 1353694..1354080 - 387 WP_005540074.1 hypothetical protein -
AANUM_RS06820 (AANUM_1385) 1354119..1355009 - 891 WP_005552698.1 WYL domain-containing transcriptional regulator -
AANUM_RS06825 (AANUM_1386) 1355528..1356916 - 1389 WP_005552695.1 tRNA 5-hydroxyuridine modification protein YegQ -
AANUM_RS06830 (AANUM_1387) 1357088..1357531 - 444 WP_005552694.1 YeeE/YedE thiosulfate transporter family protein -
AANUM_RS06835 (AANUM_1388) 1357872..1358210 + 339 WP_005540087.1 cupin domain-containing protein -
AANUM_RS06840 (AANUM_1389) 1358272..1358562 - 291 WP_005540089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AANUM_RS06845 (AANUM_1390) 1358552..1358806 - 255 WP_005540091.1 hypothetical protein Antitoxin
AANUM_RS06860 (AANUM_1391) 1359257..1360018 - 762 WP_005540094.1 DNA polymerase III subunit epsilon -
AANUM_RS06870 (AANUM_1392) 1360086..1360552 + 467 Protein_1385 ribonuclease HI -
AANUM_RS06875 (AANUM_1393) 1360640..1361971 - 1332 WP_060828875.1 3-phosphoshikimate 1-carboxyvinyltransferase -
AANUM_RS06880 (AANUM_1394) 1361982..1363079 - 1098 WP_005540103.1 histidinol-phosphate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11509.34 Da        Isoelectric Point: 10.7396

>T30619 WP_005540089.1 NZ_AP014520:c1358562-1358272 [Aggregatibacter actinomycetemcomitans NUM4039]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

>T30619 NZ_AP014520:c1358562-1358272 [Aggregatibacter actinomycetemcomitans NUM4039]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGCAAAAGTTAGGCGATACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCGGGCGACAAATTAAGAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAGACGCATATAAAAACGCAGAATTCAGACAAGCTCGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9275.49 Da        Isoelectric Point: 3.9645

>AT30619 WP_005540091.1 NZ_AP014520:c1358806-1358552 [Aggregatibacter actinomycetemcomitans NUM4039]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNHNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT30619 NZ_AP014520:c1358806-1358552 [Aggregatibacter actinomycetemcomitans NUM4039]
ATGGCAATACATCAAATTTTGACACAACAAGCCGCAAGCATTACCGATTTAAAACGGGACCCAATGGGCATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCATAACCAACCAGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATTGCTGAAGAGCGTCTGGCAACCCTTGATCCGATTGAGGTAAGC
CTTGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FYB7

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0EPW1

References