Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapD-relB/-
Location 330543..331200 Replicon chromosome
Accession NZ_AP013356
Organism Helicobacter pylori 26695-1CL

Toxin (Protein)


Gene name VapD Uniprot ID T5D7N9
Locus tag HP1CL_RS01605 Protein ID WP_000271050.1
Coordinates 330543..330827 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O25085
Locus tag HP1CL_RS01610 Protein ID WP_001134066.1
Coordinates 330808..331200 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HP1CL_RS01580 325745..326623 + 879 WP_000850703.1 carbon-nitrogen hydrolase family protein -
HP1CL_RS01585 326636..327517 + 882 WP_001040419.1 polysaccharide deacetylase -
HP1CL_RS01590 327563..327931 + 369 WP_000337920.1 hypothetical protein -
HP1CL_RS01595 327931..328896 + 966 WP_001124369.1 GTP-binding protein -
HP1CL_RS01600 328902..330047 - 1146 WP_001263616.1 YbfB/YjiJ family MFS transporter -
HP1CL_RS01605 330543..330827 - 285 WP_000271050.1 endoribonuclease VapD Toxin
HP1CL_RS01610 330808..331200 - 393 WP_001134066.1 hypothetical protein Antitoxin
HP1CL_RS01615 331800..334037 - 2238 WP_000716253.1 outer membrane beta-barrel protein -
HP1CL_RS01620 334334..335089 - 756 WP_000934548.1 HugZ family heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11188.74 Da        Isoelectric Point: 4.8896

>T30613 WP_000271050.1 NZ_AP013356:c330827-330543 [Helicobacter pylori 26695-1CL]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Download         Length: 285 bp

>T30613 NZ_AP013356:c330827-330543 [Helicobacter pylori 26695-1CL]
ATGTATGCTTTAGCGTTTGATTTAAAGATTGAGATTTTAAAAAAAGAATACGGAGAACCCTACAATAAAGCCTATGATGA
TTTAAGGCAAGAATTAGAGCTATTAGGGTTTGAATGGACTCAAGGGAGCGTTTATGTTAATTATTCTAAAGAAAACACTC
TAGCACAAGTCTATAAAGCGATCAATAAACTCTCTCAAATTGAGTGGTTTAAAAAGTCTGTTAGGGATATTAGAGCGTTT
AAGGTGGAGGACTTTAGCGATTTTACTGAGATTGTGAAATCCTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15304.38 Da        Isoelectric Point: 7.1101

>AT30613 WP_001134066.1 NZ_AP013356:c331200-330808 [Helicobacter pylori 26695-1CL]
MPNTTAKKDYTKYSEKQLFNLIHQLERKIKKMQNDRISFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNIETQQAMRDALNGINLTQIDSLDDFTNELKRENSKGFENVCFSV

Download         Length: 393 bp

>AT30613 NZ_AP013356:c331200-330808 [Helicobacter pylori 26695-1CL]
ATGCCTAACACCACCGCCAAAAAAGACTACACAAAATACAGCGAAAAACAGCTTTTTAATTTAATCCATCAATTAGAGCG
AAAAATCAAAAAGATGCAAAATGATAGAATTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCGTTAAATGAACTCTTGCAAAAAATCAGTCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCATGAGATCCCAAACATTGAAACGCAACAAGCCATGAGAGATGCGTTAAATGGAATTAATCTCACTCAAATTGATAG
TTTAGATGATTTTACAAACGAGTTAAAAAGAGAAAATAGTAAAGGTTTTGAAAATGTATGCTTTAGCGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3UI3

Antitoxin

Source ID Structure
AlphaFold DB A0A1Y3E322

References