Detailed information of TA system TA030601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2093913..2094464
• Replicon: chromosome
• Accession: NZ_AP013072
• Organism: Streptococcus anginosus subsp. whileyi MAS624

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I0SIJ7
• Locus tag: ANG_RS10400
• Protein ID: WP_003034637.1
• Coordinates: 2094186..2094464 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I0SII5
• Locus tag: ANG_RS10395
• Protein ID: WP_003034600.1
• Coordinates: 2093913..2094185 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ANG_RS10365	2089313..2090335	-	1023	WP_003034698.1	radical SAM protein	-
ANG_RS10370	2090328..2090846	-	519	WP_003034614.1	hypothetical protein	-
ANG_RS10375	2090873..2091400	-	528	WP_003034714.1	hypothetical protein	-
ANG_RS10380	2091647..2092000	+	354	WP_003034700.1	hypothetical protein	-
ANG_RS10385	2092020..2092871	-	852	WP_003034663.1	ImmA/IrrE family metallo-endopeptidase	-
ANG_RS10390	2092878..2093240	-	363	WP_003034723.1	helix-turn-helix domain-containing protein	-
ANG_RS10395	2093913..2094185	+	273	WP_003034600.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
ANG_RS10400	2094186..2094464	+	279	WP_003034637.1	type II toxin-antitoxin system YafQ family toxin	Toxin
ANG_RS10405	2094593..2094829	+	237	WP_003034655.1	hypothetical protein	-
ANG_RS10410	2094860..2095087	+	228	WP_003034721.1	hypothetical protein	-
ANG_RS10415	2095202..2095516	+	315	WP_000406626.1	hypothetical protein	-
ANG_RS10420	2095539..2095949	+	411	WP_003034661.1	DUF961 family protein	-
ANG_RS10425	2095956..2097614	+	1659	WP_003034653.1	cell division protein FtsK	-
ANG_RS10430	2097878..2098144	+	267	WP_003034688.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
ANG_RS10435	2098137..2098391	+	255	WP_003034719.1	Txe/YoeB family addiction module toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2087414..2109746	22332

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-83)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10876.72 Da
• Isoelectric Point: 8.0384

>T30601 WP_003034637.1 NZ_AP013072:2094186-2094464 [Streptococcus anginosus subsp. whileyi MAS624]
MYQVKFTSAFKKSYKRIKKRGLEIALLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Nucleotide

• Length: 279 bp

>T30601 NZ_AP013072:2094186-2094464 [Streptococcus anginosus subsp. whileyi MAS624]
ATGTATCAAGTCAAGTTTACCTCTGCTTTTAAAAAGAGCTATAAACGGATTAAAAAGCGAGGCTTAGAGATAGCACTCTT
AGATGAAGTGATTGAAAAACTCCGTCTAGGTCAGACACTAGAAGAAAAATACCGTGACCATGAACTCAAAGGAAACTTTG
TTGGCTTTAGGGAATGTCACATCAAGCCAGATTGGCTCTTGATTTATCTGATTGAAGACGATATTTTGACATTGACTTTA
GCTGATACAGGCAGTCATGCGGATTTGTTTAAGATGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9932.42 Da
• Isoelectric Point: 5.0337

>AT30601 WP_003034600.1 NZ_AP013072:2093913-2094185 [Streptococcus anginosus subsp. whileyi MAS624]
MATVPTQIRINETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDETVASYDN
LADLKKALEV

Nucleotide

• Length: 273 bp

>AT30601 NZ_AP013072:2093913-2094185 [Streptococcus anginosus subsp. whileyi MAS624]
ATGGCAACTGTACCAACTCAAATTCGGATTAATGAAACTGTCAAAGCCCAAGCAACTTCATTATTTAATGACTTGGGGAT
GGATATGTCTAGTGCAGTCAATATTTTTCTTCGGCAATGTCTATTGCGTGGTGGACTTCCTTTCACGGTTGAAGTTCCCA
ATTATAGCCAAAAGACCTTAGAAGCTCTGGCAGAAGCTAAACGAATCTCTCGTGATGAAACGGTCGCTTCTTATGACAAT
CTAGCAGATTTAAAGAAGGCTCTGGAAGTTTAG

Structures

Toxin

• AlphaFold DB: I0SIJ7

Antitoxin

• AlphaFold DB: I0SII5