Detailed information of TA system TA030600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 216430..217037
• Replicon: chromosome
• Accession: NZ_AP013072
• Organism: Streptococcus anginosus subsp. whileyi MAS624

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I0S7M8
• Locus tag: ANG_RS01135
• Protein ID: WP_003038349.1
• Coordinates: 216846..217037 (-)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: I0S7P0
• Locus tag: ANG_RS01130
• Protein ID: WP_003038371.1
• Coordinates: 216430..216810 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ANG_RS01115	212234..214795	+	2562	WP_020999883.1	DNA mismatch repair protein MutS	-
ANG_RS01120	214983..215441	-	459	WP_003038399.1	DUF3021 domain-containing protein	-
ANG_RS01125	215438..215878	-	441	WP_003032335.1	LytTR family transcriptional regulator	-
ANG_RS01130	216430..216810	-	381	WP_003038371.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ANG_RS01135	216846..217037	-	192	WP_003038349.1	type II toxin-antitoxin system HicA family toxin	Toxin
ANG_RS01140	217568..218008	-	441	WP_003038422.1	ArpU family transcriptional regulator	-
ANG_RS01145	218257..219108	-	852	WP_020999881.1	ATP-binding protein	-
ANG_RS01150	219123..219929	-	807	WP_003038339.1	phage replisome organizer N-terminal domain-containing protein	-
ANG_RS01155	219938..220207	-	270	WP_003038376.1	hypothetical protein	-
ANG_RS01160	220209..220544	-	336	WP_003038362.1	hypothetical protein	-
ANG_RS01165	220541..220777	-	237	WP_003038392.1	hypothetical protein	-
ANG_RS11145	220767..220943	-	177	WP_003027795.1	hypothetical protein	-
ANG_RS01170	220940..221218	-	279	WP_003027794.1	hypothetical protein	-
ANG_RS11150	221561..221728	-	168	WP_003038324.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	216430..229198	12768

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-62)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-108)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7192.29 Da
• Isoelectric Point: 8.6749

>T30600 WP_003038349.1 NZ_AP013072:c217037-216846 [Streptococcus anginosus subsp. whileyi MAS624]
MPLTGKEMAKLAEKNGWVEIRQNGSHHHFKHEDFDYIVTIPIHGNKDLGRGLESKILKDLGLK

Nucleotide

• Length: 192 bp

>T30600 NZ_AP013072:c217037-216846 [Streptococcus anginosus subsp. whileyi MAS624]
ATGCCACTTACAGGAAAAGAAATGGCAAAGCTAGCCGAGAAAAATGGTTGGGTAGAAATCCGACAGAACGGCAGCCATCA
CCATTTCAAACATGAAGATTTTGATTATATAGTGACTATCCCAATCCATGGAAACAAGGATTTAGGAAGAGGGCTAGAAA
GCAAAATCCTGAAAGATTTGGGGCTGAAATAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 14150.14 Da
• Isoelectric Point: 4.5235

>AT30600 WP_003038371.1 NZ_AP013072:c216810-216430 [Streptococcus anginosus subsp. whileyi MAS624]
MLKSYPAIFHKEEDGSYWVEFPEFGGGTQGANVEEALKNAREMLESVLAAYIDEGLDMPKPSDIMALTVKDGFVSMIQAD
PTPFIRNNKAVRKNVTVPEWLVRLADREKVNYSEVLTQALETKLQA

Nucleotide

• Length: 381 bp

>AT30600 NZ_AP013072:c216810-216430 [Streptococcus anginosus subsp. whileyi MAS624]
ATGTTAAAATCATATCCAGCAATTTTTCATAAAGAGGAAGACGGTTCTTATTGGGTAGAATTTCCAGAGTTTGGAGGAGG
CACACAAGGGGCAAATGTTGAAGAAGCCTTGAAAAATGCCCGTGAAATGCTTGAGAGTGTTTTAGCTGCTTACATAGACG
AAGGATTAGATATGCCAAAGCCTAGCGACATCATGGCTTTAACCGTTAAAGACGGCTTTGTTAGCATGATACAAGCAGAC
CCTACCCCGTTTATTCGCAACAATAAAGCCGTTAGAAAGAATGTGACTGTCCCTGAATGGCTAGTAAGATTAGCGGATCG
TGAAAAAGTAAATTATTCTGAGGTGCTAACTCAAGCCCTAGAAACAAAGTTACAAGCCTAG

Structures

Toxin

• AlphaFold DB: I0S7M8

Antitoxin

• AlphaFold DB: I0S7P0