Detailed information of TA system TA030598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4623830..4624431
• Replicon: chromosome
• Accession: NZ_AP013063
• Organism: Serratia marcescens SM39

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SM39_RS21470
• Protein ID: WP_033636540.1
• Coordinates: 4624051..4624431 (+)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A086G6A0
• Locus tag: SM39_RS21465
• Protein ID: WP_004933932.1
• Coordinates: 4623830..4624051 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM39_RS21450	4618978..4619955	+	978	WP_033636542.1	glyoxylate/hydroxypyruvate reductase GhrB	-
SM39_RS26290	4619957..4620109	-	153	WP_019455508.1	hypothetical protein	-
SM39_RS21455	4620306..4622369	+	2064	WP_041037317.1	alpha-amylase	-
SM39_RS21460	4622505..4623755	+	1251	WP_004933935.1	valine--pyruvate transaminase	-
SM39_RS21465	4623830..4624051	+	222	WP_004933932.1	ribbon-helix-helix domain-containing protein	Antitoxin
SM39_RS21470	4624051..4624431	+	381	WP_033636540.1	type II toxin-antitoxin system VapC family toxin	Toxin
SM39_RS21475	4624442..4626100	-	1659	WP_041037319.1	putative transporter	-
SM39_RS21480	4626267..4626695	-	429	WP_004933922.1	heat shock chaperone IbpB	-
SM39_RS21485	4626796..4627209	-	414	WP_004933919.1	heat shock chaperone IbpA	-
SM39_RS21490	4627520..4627867	+	348	WP_033636538.1	YceK/YidQ family lipoprotein	-
SM39_RS21495	4627898..4629178	-	1281	WP_041037321.1	DUF3748 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-102)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 14185.53 Da
• Isoelectric Point: 7.3170

>T30598 WP_033636540.1 NZ_AP013063:4624051-4624431 [Serratia marcescens SM39]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPALELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Nucleotide

• Length: 381 bp

>T30598 NZ_AP013063:4624051-4624431 [Serratia marcescens SM39]
ATGGTGGCTCAACGGGCGTTATTCGACACCAATATCCTGATCGATTATCTCAACGGCATTCCTCAAGCCAAAGACGTTCT
GACCGAATACCACATCAACCCGGCTATTAGCGCCATCACCTGGATGGAAGTGATGGTGGGTGCCAAAAAACAGGGGCCGG
CGCTGGAGCTGAAAACGCGCCAGTTTTTAGGGCAATTCCTGCTGTTGCCTATTACCGATGAAGTTGCCGAACGCGCCGTA
GAATTGCGCCACTCACAGCATGTGAAGCTGCCGGACGCCATTATCTGGGCCACCGCGCAGGTGGGGTTCCGGACGCTCAT
CTCCCGCAACCCCAAAGATTTCGGCACTGACAATGGCGTGTTAATGCCTTACCGGCTGTAG

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8593.53 Da
• Isoelectric Point: 4.4791

>AT30598 WP_004933932.1 NZ_AP013063:4623830-4624051 [Serratia marcescens SM39]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLTENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Nucleotide

• Length: 222 bp

>AT30598 NZ_AP013063:4623830-4624051 [Serratia marcescens SM39]
ATGACTCGCATCGTGATCGATTTACCTGAAGAAGACCTGCGGCAGCTCGACAATCTGAAAAATATCCGCCACGTTCCCCG
GGCCGAAATCATCCGTCAGGCCGTCTCCCGTTATCTGACGGAGAACCACGTTGAAGATCCCAGCAATGCTTTCGGGCTCT
GGTCCGGGGCGATGGGCGATGGCGTAGACTACGAAAATCGTCAGCGCGAGGAGTGGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A086G6A0