Detailed information of TA system TA030597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4582952..4583487
• Replicon: chromosome
• Accession: NZ_AP013063
• Organism: Serratia marcescens SM39

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SM39_RS21290
• Protein ID: WP_033649525.1
• Coordinates: 4582952..4583227 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A5C7DDR0
• Locus tag: SM39_RS21295
• Protein ID: WP_041037283.1
• Coordinates: 4583227..4583487 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM39_RS21270	4578770..4579762	-	993	WP_041037275.1	acyltransferase	-
SM39_RS21275	4579980..4581227	+	1248	WP_041038165.1	MFS transporter	-
SM39_RS21280	4581281..4581907	-	627	WP_041037277.1	LysE family translocator	-
SM39_RS21285	4582029..4582940	+	912	WP_041037279.1	LysR family transcriptional regulator	-
SM39_RS21290	4582952..4583227	-	276	WP_033649525.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SM39_RS21295	4583227..4583487	-	261	WP_041037283.1	ribbon-helix-helix domain-containing protein	Antitoxin
SM39_RS21300	4583570..4585411	-	1842	WP_041037285.1	selenocysteine-specific translation elongation factor	-
SM39_RS21305	4585408..4586802	-	1395	WP_041037287.1	L-seryl-tRNA(Sec) selenium transferase	-
SM39_RS21310	4586872..4587477	-	606	WP_033636563.1	glutathione S-transferase	-
SM39_RS21315	4587518..4588168	-	651	WP_033636562.1	DcrB-related protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-43)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10596.34 Da
• Isoelectric Point: 10.3377

>T30597 WP_033649525.1 NZ_AP013063:c4583227-4582952 [Serratia marcescens SM39]
MELKWTSKALSDLARLFEFLALVNRTAAANSVKALVAAPKALLDNSRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Nucleotide

• Length: 276 bp

>T30597 NZ_AP013063:c4583227-4582952 [Serratia marcescens SM39]
ATGGAGTTAAAATGGACGAGTAAGGCGCTATCGGATTTGGCGCGTTTGTTTGAGTTTCTTGCCTTGGTTAACCGTACTGC
GGCAGCGAATTCGGTGAAGGCCTTGGTCGCCGCGCCTAAAGCGTTGCTTGATAATTCTCGCCTGGGTGAAAGACTGGACG
AGTTTTTACCGCAGGAAGTGAGGCGTATTCTGGTCGGCCGTTATGAGATACGTTACCAGGTGCAGCCGGCAACGATTTAT
GTTCTGCGTATTTGGCATACCCGCGAAGAGCGATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9653.95 Da
• Isoelectric Point: 4.5084

>AT30597 WP_041037283.1 NZ_AP013063:c4583487-4583227 [Serratia marcescens SM39]
MNTKVITAHVPLPLAEKVDEMAAKLDRSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Nucleotide

• Length: 261 bp

>AT30597 NZ_AP013063:c4583487-4583227 [Serratia marcescens SM39]
ATGAATACGAAAGTCATCACCGCTCATGTGCCGCTGCCTTTGGCTGAAAAGGTGGATGAAATGGCCGCCAAACTTGACCG
CTCACGGGGATGGATAGTGAAGCAAGCCCTCGCCGCCTGGCTTGAGCAAGAGGAAGAGCGCCGTCGATTAACGCTGGCGG
CGCTGGCCGATGTCGAACAGCAAAACGTTATCGATCATGAGTCGGTAGAAGCCTGGGCTGCCAGCCTGGACAGTGACGAT
CCGCTGCCGGTACCGCGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5C7DDR0