Detailed information of TA system TA030595

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3857198..3857956
• Replicon: chromosome
• Accession: NZ_AP013063
• Organism: Serratia marcescens SM39

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: SM39_RS17990
• Protein ID: WP_041036757.1
• Coordinates: 3857198..3857575 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: SM39_RS17995
• Protein ID: WP_163181168.1
• Coordinates: 3857627..3857956 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM39_RS17960	3852822..3854663	+	1842	WP_033636080.1	RNA polymerase sigma factor RpoD	-
SM39_RS17965	3854738..3855226	-	489	WP_033654812.1	G/U mismatch-specific DNA glycosylase	-
SM39_RS17975	3855551..3856396	-	846	WP_041038127.1	DUF4942 domain-containing protein	-
SM39_RS17980	3856477..3856680	-	204	WP_041036753.1	DUF957 domain-containing protein	-
SM39_RS17985	3856710..3857201	-	492	WP_041036755.1	hypothetical protein	-
SM39_RS17990	3857198..3857575	-	378	WP_041036757.1	TA system toxin CbtA family protein	Toxin
SM39_RS17995	3857627..3857956	-	330	WP_163181168.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
SM39_RS18000	3858013..3858234	-	222	WP_041036761.1	DUF987 domain-containing protein	-
SM39_RS18005	3858249..3858728	-	480	WP_041036763.1	DNA repair protein RadC	-
SM39_RS18010	3858740..3859219	-	480	WP_041036765.1	antirestriction protein	-
SM39_RS18015	3859490..3860308	-	819	WP_041036766.1	DUF945 domain-containing protein	-
SM39_RS25520	3860398..3861336	-	939	WP_080335451.1	hypothetical protein	-
SM39_RS18025	3861402..3861812	-	411	WP_041038131.1	hypothetical protein	-
SM39_RS18030	3861926..3862141	-	216	WP_041036768.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13901.82 Da
• Isoelectric Point: 5.0875

>T30595 WP_041036757.1 NZ_AP013063:c3857575-3857198 [Serratia marcescens SM39]
MQTQPLSSTQEASPRPTPVEIWQQLLIYLLEQHYGLSLNDTPFGTDGVIPEHIDAGISLCDAVNFIVEKYDLVRIDRRSV
SAETQSLLISSIDILRARKACGLMTRNGYRMVTDITTGKYSGATQ

Nucleotide

• Length: 378 bp

>T30595 NZ_AP013063:c3857575-3857198 [Serratia marcescens SM39]
ATGCAAACCCAACCACTATCCTCCACGCAGGAGGCTTCGCCACGTCCGACGCCCGTTGAAATCTGGCAGCAACTTCTTAT
ATATCTGCTGGAACAGCATTATGGCCTTTCACTTAACGACACTCCGTTTGGCACCGATGGTGTCATTCCGGAACATATTG
ACGCAGGTATTTCACTGTGCGACGCGGTGAATTTCATCGTCGAAAAGTACGATCTTGTCCGTATCGATCGTCGCAGTGTC
AGTGCAGAAACACAGTCCCTGCTCATCAGCAGTATTGATATACTCCGCGCCCGTAAGGCCTGTGGATTGATGACGCGCAA
CGGCTACAGAATGGTAACCGATATCACCACCGGCAAATACAGCGGAGCGACTCAATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12145.84 Da
• Isoelectric Point: 6.6283

>AT30595 WP_163181168.1 NZ_AP013063:c3857956-3857627 [Serratia marcescens SM39]
ITDPWWGLKRSITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPVLLRQLELMLVSGELSPRHQHCVTLYA
KGLTCEADSLGSHGYMYVAIYPTPSEATA

Nucleotide

• Length: 330 bp

>AT30595 NZ_AP013063:c3857956-3857627 [Serratia marcescens SM39]
ATCACTGACCCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTTTGGCGCTCGCCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTCGCTGACCGCGCCAGTATCACCGGGCAGTTCAGCGACGCGGATTTACGCCATCTCGACCAGGCATTTCCGG
TACTGCTCAGACAACTGGAGTTAATGCTGGTTTCCGGTGAGCTCAGTCCCCGCCATCAGCACTGTGTCACGTTATACGCA
AAAGGGCTGACCTGCGAGGCGGACAGCCTCGGCTCGCATGGATACATGTACGTAGCGATTTACCCGACACCATCTGAAGC
AACCGCGTAA