Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3596748..3597417 Replicon chromosome
Accession NZ_AP013063
Organism Serratia marcescens SM39

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag SM39_RS16815 Protein ID WP_041036558.1
Coordinates 3596748..3597170 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag SM39_RS16820 Protein ID WP_004931679.1
Coordinates 3597151..3597417 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM39_RS16795 3592637..3593155 + 519 WP_033635825.1 flavodoxin FldB -
SM39_RS16800 3593193..3594557 - 1365 WP_041036554.1 cell envelope integrity protein CreD -
SM39_RS16805 3594638..3596056 - 1419 WP_033654070.1 two-component system sensor histidine kinase CreC -
SM39_RS16810 3596053..3596748 - 696 WP_041036556.1 two-component system response regulator CreB -
SM39_RS16815 3596748..3597170 - 423 WP_041036558.1 protein YgfX Toxin
SM39_RS16820 3597151..3597417 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
SM39_RS16825 3597738..3598730 + 993 WP_041036561.1 tRNA-modifying protein YgfZ -
SM39_RS16830 3598769..3599266 - 498 WP_033649451.1 DUF2165 domain-containing protein -
SM39_RS16835 3599417..3600091 - 675 WP_038871224.1 hemolysin III family protein -
SM39_RS16840 3600275..3600883 + 609 WP_025304127.1 HD domain-containing protein -
SM39_RS16845 3600916..3601842 - 927 WP_033635835.1 ribokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3590692..3656730 66038


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16441.56 Da        Isoelectric Point: 10.8114

>T30594 WP_041036558.1 NZ_AP013063:c3597170-3596748 [Serratia marcescens SM39]
VAQWRCDIRISWRTQLFSLLAHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAAQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLLPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGDGEDP

Download         Length: 423 bp

>T30594 NZ_AP013063:c3597170-3596748 [Serratia marcescens SM39]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGGCCCACGGCGTGTTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAAGGTTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGCGCAGGGCGAGCTGCGGCTGCTGGCGGACCGGCGCTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGCTGACGCTGCTGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTGACGGCGAGGATCCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT30594 WP_004931679.1 NZ_AP013063:c3597417-3597151 [Serratia marcescens SM39]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT30594 NZ_AP013063:c3597417-3597151 [Serratia marcescens SM39]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGCCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAGTACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGCGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References