Detailed information of TA system TA030592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3263825..3264481
• Replicon: chromosome
• Accession: NZ_AP013063
• Organism: Serratia marcescens SM39

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2V4G0W2
• Locus tag: SM39_RS15240
• Protein ID: WP_041036282.1
• Coordinates: 3263825..3264214 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: SM39_RS15245
• Protein ID: WP_004941563.1
• Coordinates: 3264218..3264481 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM39_RS15225	3260292..3261722	+	1431	WP_041036278.1	multidrug transporter subunit MdtD	-
SM39_RS15230	3261719..3263101	+	1383	WP_041036280.1	two-component system sensor histidine kinase BaeS	-
SM39_RS15235	3263101..3263817	+	717	WP_033635542.1	two-component system response regulator BaeR	-
SM39_RS15240	3263825..3264214	-	390	WP_041036282.1	type II toxin-antitoxin system VapC family toxin	Toxin
SM39_RS15245	3264218..3264481	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
SM39_RS15250	3264821..3265159	+	339	WP_033648841.1	YegP family protein	-
SM39_RS15255	3265340..3266692	+	1353	WP_033635545.1	tRNA 5-hydroxyuridine modification protein YegQ	-
SM39_RS15260	3267159..3268064	+	906	WP_041036284.1	lipid kinase YegS	-
SM39_RS15265	3268354..3269403	+	1050	WP_033635553.1	class I fructose-bisphosphate aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14309.56 Da
• Isoelectric Point: 7.8786

>T30592 WP_041036282.1 NZ_AP013063:c3264214-3263825 [Serratia marcescens SM39]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMEKKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T30592 NZ_AP013063:c3264214-3263825 [Serratia marcescens SM39]
ATGTACATGTTTGATACCAACACCGTCAGCCACTTGTTTCGGCAGCATCCGCAGGTGCTTAACGTCATGGAAAAGCTCCC
GCCTTCTGCCGTATGTATTTCCAGCGTCACGGAGGCGGAACTGCTTTACGGTGTGGCTAAACGGCGGAACAAGGCGTTGC
AAAGCATGGTCGAGGCCTTTCTTGCCGCGGTGACGGTCTATGCATGGGATAGCGAGGCCGCCCGCTGCTACGGTGAAATG
CGCGCGAACATGGAGAAAAAGGGCAAAATCATGGGCGCGCTGGATCAACTGATCGCCGCTCACGCGCAGAGCCGTGGCGC
GACGCTGGTGACCAACGATCGCGCATTCGCCATGGTGCCCGGGTTGGCGGTTGAAGACTGGACGCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT30592 WP_004941563.1 NZ_AP013063:c3264481-3264218 [Serratia marcescens SM39]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT30592 NZ_AP013063:c3264481-3264218 [Serratia marcescens SM39]
ATGGAAAGAATCGCAAAGCTGTTTAAAAACGGCAGAAATCAGGCGGTGAGGTTACCGGTGGAATTTGAATTTGATACGGA
TCGTGTCTATATCCGTCGCGATCGGGAGGGCAACGTGATTTTATCCAAATATCCGGCAAAGCCGGACAGCTGGGCACCGC
TGCTGAGCATTATCGCCCAAACGCCGGTGCCGCAAGAGTTTCTTGGCGCGGAAGATCGTCAGCAAGGGGTTGCAGACCGC
GATCCATTCTCAGAGGAAGAGTAG

Structures

Toxin

• AlphaFold DB: A0A2V4G0W2