Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2497917..2498548 Replicon chromosome
Accession NZ_AP013063
Organism Serratia marcescens SM39

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7D7C3
Locus tag SM39_RS11835 Protein ID WP_033640020.1
Coordinates 2497917..2498315 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C7D7A2
Locus tag SM39_RS11840 Protein ID WP_041035628.1
Coordinates 2498315..2498548 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM39_RS11815 2493017..2493832 - 816 WP_041035622.1 5'-nucleotidase, lipoprotein e(P4) family -
SM39_RS11820 2494161..2494565 - 405 WP_041035624.1 flagellar protein FlhE -
SM39_RS11825 2494565..2496643 - 2079 WP_033635001.1 flagellar biosynthesis protein FlhA -
SM39_RS11830 2496636..2497787 - 1152 WP_015378261.1 flagellar type III secretion system protein FlhB -
SM39_RS11835 2497917..2498315 - 399 WP_033640020.1 type II toxin-antitoxin system VapC family toxin Toxin
SM39_RS11840 2498315..2498548 - 234 WP_041035628.1 antitoxin Antitoxin
SM39_RS11845 2498673..2499317 - 645 WP_004934858.1 protein phosphatase CheZ -
SM39_RS11850 2499328..2499717 - 390 WP_041035631.1 chemotaxis response regulator CheY -
SM39_RS11855 2499820..2500869 - 1050 WP_033635003.1 chemotaxis response regulator protein-glutamate methylesterase -
SM39_RS11860 2500869..2501741 - 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
SM39_RS11865 2501779..2503395 - 1617 WP_033653630.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14918.11 Da        Isoelectric Point: 8.4955

>T30590 WP_033640020.1 NZ_AP013063:c2498315-2497917 [Serratia marcescens SM39]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVEKSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAALERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T30590 NZ_AP013063:c2498315-2497917 [Serratia marcescens SM39]
ATGTTCAGTCATATGCTGGACACCAACATTGTTATCTATGTCATTAAGCGCCGGCCGCTGGAAGTGCTGGAGGCATTCAA
TCGCTATGCAGGTAAAATGGTCATTTCGTCAATCACCTATGGCGAATTGGTTCACGGGGTGGAGAAAAGCGCTCGCCCAG
CGGTGAACGCCAGAGTGGTTGAGGATTTTGTCTCCCGATTGGACATTCTCGATTACAGCGCCAAAGCGGCATCGCACTAC
GGCAACATCCGGGCTGCGCTGGAACGCCAGGGAACGCCTATTGGCGTAAACGATCTACATATCGCCGGGCATGCGCGCAG
CGAAGGATTGATCCTGGTGACCAATAATCGACGCGAATTTGAACGCGTTGAGGGTTTACGGCTGGAAAATTGGTTGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8871.88 Da        Isoelectric Point: 4.7815

>AT30590 WP_041035628.1 NZ_AP013063:c2498548-2498315 [Serratia marcescens SM39]
MTLGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT30590 NZ_AP013063:c2498548-2498315 [Serratia marcescens SM39]
ATGACGTTAGGTTCTGTCTTTACCAATAATCGGACACAGGCTGTACGCTTGCCTGCAGAGGTGCGTTTCCCTGATACCGT
TTCTAAAGTGACCGTCCGCGTAGTGGGCAAAGAGCGCATTCTTGCCCCCCTGGAGAATACCTGGGACAGTTTCTTCTGTG
CGGAAAATGAGGTGAGCGATGATTTCCTCAATGAACGTGCCGGGCAGCACCAGCGCGAGCGGGAAGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5C7D7C3

Antitoxin

Source ID Structure
AlphaFold DB A0A5C7D7A2

References