Detailed information of TA system TA030581

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1136100..1136625
• Replicon: chromosome
• Accession: NZ_AP013063
• Organism: Serratia marcescens SM39

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SM39_RS05460
• Protein ID: WP_041034302.1
• Coordinates: 1136100..1136384 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B4GIN1
• Locus tag: SM39_RS05465
• Protein ID: WP_004928423.1
• Coordinates: 1136374..1136625 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM39_RS05435	1131360..1132493	+	1134	WP_033637812.1	putrescine ABC transporter ATP-binding subunit PotG	-
SM39_RS05440	1132518..1133480	+	963	WP_033646669.1	putrescine ABC transporter permease PotH	-
SM39_RS05445	1133477..1134322	+	846	WP_016928360.1	putrescine ABC transporter permease PotI	-
SM39_RS05450	1134427..1134906	+	480	WP_048321404.1	YbjO family protein	-
SM39_RS05455	1134976..1136103	+	1128	WP_041034300.1	23S rRNA (uracil(747)-C(5))-methyltransferase RlmC	-
SM39_RS05460	1136100..1136384	-	285	WP_041034302.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SM39_RS05465	1136374..1136625	-	252	WP_004928423.1	prevent-host-death protein	Antitoxin
SM39_RS05470	1136727..1137461	-	735	WP_041034305.1	arginine ABC transporter substrate-binding protein	-
SM39_RS05475	1137661..1138329	-	669	WP_033637817.1	arginine ABC transporter permease ArtM	-
SM39_RS05480	1138329..1139045	-	717	WP_033637818.1	arginine ABC transporter permease ArtQ	-
SM39_RS05485	1139055..1139786	-	732	WP_033637819.1	arginine ABC transporter substrate-binding protein	-
SM39_RS05490	1139819..1140547	-	729	WP_038884338.1	arginine ABC transporter ATP-binding protein ArtP	-
SM39_RS05495	1140812..1141354	-	543	WP_033637821.1	lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10798.92 Da
• Isoelectric Point: 10.5850

>T30581 WP_041034302.1 NZ_AP013063:c1136384-1136100 [Serratia marcescens SM39]
MTYKLEFEEHALKEFKKLSPVIREQFKKKLVSVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRVMETEIVVLVLSVGK
REHSAAYTAAKKRL

Nucleotide

• Length: 285 bp

>T30581 NZ_AP013063:c1136384-1136100 [Serratia marcescens SM39]
ATGACTTATAAGCTTGAATTCGAAGAACATGCGCTGAAGGAATTTAAAAAACTGTCCCCGGTGATCCGGGAACAGTTCAA
AAAAAAGCTGGTATCGGTATTGGTTAATCCCCACGTCCCCGCCAACAAACTCGCCGGTTTGCCCGATTGCTACAAAATCA
AACTCAGAGCATCAGGCTTTCGTTTGGTGTATCGCGTCATGGAAACGGAGATCGTGGTTCTGGTCCTGTCTGTGGGCAAA
CGCGAACATTCAGCGGCTTATACGGCTGCCAAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9108.39 Da
• Isoelectric Point: 4.5203

>AT30581 WP_004928423.1 NZ_AP013063:c1136625-1136374 [Serratia marcescens SM39]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDIELAEIVRSRMNGKRIKVNL
DDL

Nucleotide

• Length: 252 bp

>AT30581 NZ_AP013063:c1136625-1136374 [Serratia marcescens SM39]
ATGACGGTTCAACCCATTCTTGCCGATTCCGCAGTCAGCATCAGCGATTTTAAGAAATCGCCCAACGCCGCCCTTAAAGA
GGCACAAGGGCAGCCGGTCGCCGTCCTGACCAACGGTAAGATTTCGGGATATTACGTCTCACCGGAAACCTGGGAGGCTA
TCGCGGAGTACCTGGAAGATATCGAACTCGCTGAAATCGTTCGTTCACGGATGAACGGCAAACGCATTAAGGTCAATTTG
GATGACTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GIN1