Detailed information of TA system TA030580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 998670..999223
• Replicon: chromosome
• Accession: NZ_AP013063
• Organism: Serratia marcescens SM39

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A2V4FZ31
• Locus tag: SM39_RS04870
• Protein ID: WP_019454426.1
• Coordinates: 998909..999223 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: SM39_RS04865
• Protein ID: WP_039566839.1
• Coordinates: 998670..998906 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SM39_RS04850	995137..996672	+	1536	WP_041034181.1	glutathione ABC transporter substrate-binding protein GsiB	-
SM39_RS04855	996725..997645	+	921	WP_033637716.1	glutathione ABC transporter permease GsiC	-
SM39_RS04860	997655..998563	+	909	WP_049233469.1	glutathione ABC transporter permease GsiD	-
SM39_RS04865	998670..998906	+	237	WP_039566839.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
SM39_RS04870	998909..999223	+	315	WP_019454426.1	CcdB family protein	Toxin
SM39_RS04875	999263..1000105	-	843	WP_041034184.1	S-formylglutathione hydrolase	-
SM39_RS04880	1000120..1001244	-	1125	WP_041034186.1	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase	-
SM39_RS04885	1001275..1002195	-	921	WP_033654969.1	LysR family transcriptional regulator	-
SM39_RS04890	1002301..1003458	+	1158	WP_033654978.1	YbfB/YjiJ family MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11745.68 Da
• Isoelectric Point: 5.0488

>T30580 WP_019454426.1 NZ_AP013063:998909-999223 [Serratia marcescens SM39]
MQFTVYANRGNSAVYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGSTRPERLIPLIRLIDDNEYAVMTYEMASIPVRALG
AEFCDVSQYRTRIKAAIDFLLDGI

Nucleotide

• Length: 315 bp

>T30580 NZ_AP013063:998909-999223 [Serratia marcescens SM39]
ATGCAATTTACGGTGTATGCGAATAGGGGGAACAGCGCGGTTTATCCCCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGTCGAGTTGTGATCCCTTTGTTGCCCGTTGAAAAATACCCTGGGAGTACGCGACCGGAACGCTTGATCC
CGTTGATCAGATTGATTGATGACAACGAGTACGCCGTGATGACATATGAAATGGCCAGCATCCCGGTTCGGGCTTTGGGG
GCCGAGTTTTGTGATGTTTCCCAGTATCGGACCAGGATAAAAGCCGCCATCGACTTTCTTCTTGACGGTATTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9068.10 Da
• Isoelectric Point: 5.7070

>AT30580 WP_039566839.1 NZ_AP013063:998670-998906 [Serratia marcescens SM39]
MPVKQRTTQSVTMTVERSLLSRAREAGINLSATLTAALDAELRQHERIKWQEENREALEALNRFNDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT30580 NZ_AP013063:998670-998906 [Serratia marcescens SM39]
ATGCCAGTAAAACAACGAACGACGCAAAGTGTGACCATGACGGTGGAACGCAGTTTGTTGAGCCGTGCGCGTGAGGCGGG
GATTAATCTCAGCGCGACGCTAACTGCTGCTTTAGATGCTGAGTTACGTCAGCATGAGAGGATAAAATGGCAGGAAGAAA
ACCGAGAGGCGCTTGAAGCGCTTAACCGATTTAATGATGAGCATGGTTGCTTTAGCGACGAATACAGGACGTTTTAG

Structures

Toxin

• AlphaFold DB: A0A2V4FZ31