Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 461938..462559 Replicon chromosome
Accession NZ_AP013063
Organism Serratia marcescens SM39

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag SM39_RS02210 Protein ID WP_004940313.1
Coordinates 461938..462141 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag SM39_RS02215 Protein ID WP_004940312.1
Coordinates 462191..462559 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SM39_RS02185 457729..458175 + 447 WP_033653249.1 type II secretion system protein M -
SM39_RS02190 458212..459027 + 816 WP_052475390.1 A24 family peptidase -
SM39_RS02195 459024..459386 - 363 WP_041033673.1 type II secretion system pilot lipoprotein GspS -
SM39_RS02200 459640..461070 + 1431 WP_041033675.1 N-acetylglucosamine-binding protein GbpA -
SM39_RS02205 461123..461641 + 519 WP_041033677.1 cytochrome b/b6 domain-containing protein -
SM39_RS02210 461938..462141 - 204 WP_004940313.1 hemolysin expression modulator Hha Toxin
SM39_RS02215 462191..462559 - 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
SM39_RS02220 462718..463071 - 354 WP_033653245.1 hypothetical protein -
SM39_RS02225 463479..464192 + 714 WP_033647273.1 ABC transporter ATP-binding protein -
SM39_RS02230 464189..465046 + 858 WP_033637343.1 metal ABC transporter permease -
SM39_RS02235 465072..465950 + 879 WP_041033680.1 metal ABC transporter substrate-binding protein -
SM39_RS25075 466057..466197 - 141 WP_004940304.1 type B 50S ribosomal protein L36 -
SM39_RS02240 466210..466464 - 255 WP_004940303.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T30579 WP_004940313.1 NZ_AP013063:c462141-461938 [Serratia marcescens SM39]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T30579 NZ_AP013063:c462141-461938 [Serratia marcescens SM39]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCCGATCACCGTCTGGCGGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT30579 WP_004940312.1 NZ_AP013063:c462559-462191 [Serratia marcescens SM39]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT30579 NZ_AP013063:c462559-462191 [Serratia marcescens SM39]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCACCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCAGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTACGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References