Detailed information of TA system TA030577

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE(toxin)
• Location: 1373310..1373856
• Replicon: chromosome
• Accession: NZ_AP013042
• Organism: Endosymbiont of Bathymodiolus septemdierum str. Myojin knoll isolate A1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0P0UT51
• Locus tag: BSEPE_RS07250
• Protein ID: WP_066045637.1
• Coordinates: 1373310..1373615 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: BSEPE_RS07255
• Protein ID: WP_066045640.1
• Coordinates: 1373605..1373856 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSEPE_RS07245	1371632..1372975	-	1344	WP_066045634.1	YifB family Mg chelatase-like AAA ATPase	-
BSEPE_RS07250	1373310..1373615	-	306	WP_066045637.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSEPE_RS07255	1373605..1373856	-	252	WP_066045640.1	antitoxin	Antitoxin
BSEPE_RS07265	1374338..1374574	+	237	WP_066045643.1	50S ribosomal protein L28	-
BSEPE_RS07270	1374585..1374740	+	156	WP_066045648.1	50S ribosomal protein L33	-
BSEPE_RS07275	1374812..1377370	-	2559	WP_066045651.1	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase	-
BSEPE_RS07280	1377437..1378813	+	1377	WP_066045654.1	adenylosuccinate lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 12192.38 Da
• Isoelectric Point: 11.0849

>T30577 WP_066045637.1 NZ_AP013042:c1373615-1373310 [endosymbiont of Bathymodiolus septemdierum str. Myojin knoll]
MRYKLEFNEQALKEWGKLNSTIKEQFKKKLKQILENPKIPKNRLRGYENIYKIKLRQSGFRLAYKVIDNRLVVYVVAVGK
RDKNKIYNLLRQRSTKDFGSR

Nucleotide

• Length: 306 bp

>T30577 NZ_AP013042:c1373615-1373310 [endosymbiont of Bathymodiolus septemdierum str. Myojin knoll]
ATGCGTTATAAATTAGAATTTAACGAACAGGCATTAAAAGAATGGGGCAAACTAAATTCCACCATTAAAGAGCAATTTAA
AAAGAAATTAAAACAGATTTTAGAAAATCCCAAAATTCCTAAAAACAGATTGAGGGGATATGAAAATATCTATAAGATAA
AATTAAGGCAATCAGGATTTAGACTTGCATATAAAGTTATTGATAATAGATTGGTAGTCTATGTTGTTGCGGTAGGAAAA
AGAGATAAAAACAAGATTTATAACTTACTAAGACAAAGAAGCACAAAAGATTTTGGGTCTAGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9238.48 Da
• Isoelectric Point: 7.0052

>AT30577 WP_066045640.1 NZ_AP013042:c1373856-1373605 [endosymbiont of Bathymodiolus septemdierum str. Myojin knoll]
MDKILSNYSASISEFKKSPTKILNNAKGESVAILNHNTPYGYFVPSALYEQFINLADDYLLGQEVEKRANSKNKTIPVSL
DAL

Nucleotide

• Length: 252 bp

>AT30577 NZ_AP013042:c1373856-1373605 [endosymbiont of Bathymodiolus septemdierum str. Myojin knoll]
ATGGATAAGATACTATCAAACTATTCAGCAAGCATTAGCGAGTTTAAAAAATCGCCCACTAAAATATTAAACAACGCCAA
AGGCGAAAGCGTAGCAATCTTAAACCATAACACCCCTTATGGTTATTTTGTGCCAAGTGCGTTATATGAGCAATTTATAA
ACTTAGCAGATGATTATCTATTGGGGCAAGAAGTGGAAAAAAGAGCAAACAGCAAAAACAAGACAATCCCTGTTAGTTTA
GATGCGTTATAA

Structures

Toxin

• AlphaFold DB: A0A0P0UT51