Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1142974..1143448 Replicon chromosome
Accession NZ_AP013042
Organism Endosymbiont of Bathymodiolus septemdierum str. Myojin knoll isolate A1

Toxin (Protein)


Gene name pasB Uniprot ID A0A0P0UTA3
Locus tag BSEPE_RS05975 Protein ID WP_066045115.1
Coordinates 1142974..1143240 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID A0A0P0USQ6
Locus tag BSEPE_RS05980 Protein ID WP_066045116.1
Coordinates 1143224..1143448 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSEPE_RS05955 1138910..1139995 + 1086 WP_066045107.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
BSEPE_RS05960 1140007..1140453 + 447 WP_066045109.1 dCMP deaminase family protein -
BSEPE_RS05965 1140455..1142023 + 1569 WP_066045111.1 peptide chain release factor 3 -
BSEPE_RS05970 1142039..1142971 + 933 WP_066045113.1 peptide-methionine (S)-S-oxide reductase MsrA -
BSEPE_RS05975 1142974..1143240 - 267 WP_066045115.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSEPE_RS05980 1143224..1143448 - 225 WP_066045116.1 TraY domain-containing protein Antitoxin
BSEPE_RS05985 1143543..1146122 - 2580 WP_066045118.1 DNA gyrase subunit A -
BSEPE_RS05990 1146230..1147297 - 1068 WP_066045120.1 3-deoxy-7-phosphoheptulonate synthase -
BSEPE_RS05995 1147291..1148088 - 798 WP_066045121.1 GTP cyclohydrolase I FolE2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

Protein of unknown function DUF6290

(3-70)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10520.61 Da        Isoelectric Point: 11.2612

>T30576 WP_066045115.1 NZ_AP013042:c1143240-1142974 [endosymbiont of Bathymodiolus septemdierum str. Myojin knoll]
MAWKIKFSARLKKDFRRIGAQQLLKIKAYLEKVKALDNPRKLGKPLKSRFKGLWRYRVGDYRLVCEIQDQDLIVLVVRVA
SRKEVYNR

Download         Length: 267 bp

>T30576 NZ_AP013042:c1143240-1142974 [endosymbiont of Bathymodiolus septemdierum str. Myojin knoll]
TTGGCTTGGAAGATTAAATTTAGTGCAAGGTTAAAAAAAGACTTTAGAAGGATAGGTGCTCAACAATTATTAAAAATAAA
AGCTTATCTTGAAAAGGTCAAAGCACTCGACAATCCTAGAAAGCTTGGAAAGCCGCTAAAAAGTCGATTCAAAGGTTTGT
GGCGTTATCGTGTTGGTGATTATCGACTTGTTTGTGAGATACAAGATCAAGATTTGATTGTATTGGTCGTTAGAGTTGCA
AGCCGTAAAGAAGTTTATAATCGTTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8579.69 Da        Isoelectric Point: 4.0800

>AT30576 WP_066045116.1 NZ_AP013042:c1143448-1143224 [endosymbiont of Bathymodiolus septemdierum str. Myojin knoll]
MLAIRLPETIEQRLENLATLTGRTKTYYAREAIIDKIEDLEEVYLAEKELEDIRSGKVSVISSEEMWSEFGLED

Download         Length: 225 bp

>AT30576 NZ_AP013042:c1143448-1143224 [endosymbiont of Bathymodiolus septemdierum str. Myojin knoll]
ATGCTTGCAATACGATTACCTGAAACGATAGAACAGCGGTTAGAAAATTTGGCTACCTTAACAGGCAGAACTAAAACTTA
TTATGCGCGTGAAGCGATTATCGACAAAATTGAGGATTTAGAAGAAGTTTACCTTGCTGAAAAAGAGTTGGAAGATATTA
GGTCAGGAAAGGTATCTGTTATTTCATCTGAAGAGATGTGGAGCGAATTTGGCTTGGAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P0UTA3

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0USQ6

References