Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mbcAT/RES-Xre |
| Location | 10747..11645 | Replicon | plasmid pMAH135 |
| Accession | NZ_AP012556 | ||
| Organism | Mycobacterium avium subsp. hominissuis TH135 | ||
Toxin (Protein)
| Gene name | mbcT | Uniprot ID | A0A859PX34 |
| Locus tag | MAH_RS22805 | Protein ID | WP_023870434.1 |
| Coordinates | 11085..11645 (+) | Length | 187 a.a. |
Antitoxin (Protein)
| Gene name | mbcA | Uniprot ID | A0A859PYE6 |
| Locus tag | MAH_RS22800 | Protein ID | WP_023870435.1 |
| Coordinates | 10747..11088 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MAH_RS22765 | 5781..6623 | + | 843 | WP_023870443.1 | ParB/RepB/Spo0J family partition protein | - |
| MAH_RS22770 | 6839..7090 | + | 252 | WP_023870442.1 | ribbon-helix-helix protein, CopG family | - |
| MAH_RS22775 | 7087..7503 | + | 417 | WP_023870441.1 | type II toxin-antitoxin system VapC family toxin | - |
| MAH_RS22780 | 7608..8048 | - | 441 | WP_023870440.1 | hypothetical protein | - |
| MAH_RS24735 | 8224..8385 | + | 162 | WP_023870439.1 | hypothetical protein | - |
| MAH_RS24610 | 9507..10658 | - | 1152 | WP_023870436.1 | hypothetical protein | - |
| MAH_RS22800 | 10747..11088 | + | 342 | WP_023870435.1 | DUF2384 domain-containing protein | Antitoxin |
| MAH_RS22805 | 11085..11645 | + | 561 | WP_023870434.1 | RES domain-containing protein | Toxin |
| MAH_RS22810 | 11861..12211 | - | 351 | WP_023870433.1 | hypothetical protein | - |
| MAH_RS22815 | 12208..13911 | - | 1704 | WP_158423352.1 | WXG100 family type VII secretion target | - |
| MAH_RS22820 | 13928..14233 | - | 306 | WP_023870373.1 | hypothetical protein | - |
| MAH_RS22825 | 14309..14614 | - | 306 | WP_134798478.1 | hypothetical protein | - |
| MAH_RS22830 | 14644..16188 | - | 1545 | WP_134798479.1 | DUF4226 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | esxN / eccA5 / esxN | 1..194711 | 194711 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 187 a.a. Molecular weight: 20272.58 Da Isoelectric Point: 4.8677
>T30574 WP_023870434.1 NZ_AP012556:11085-11645 [Mycobacterium avium subsp. hominissuis TH135]
VSDALDEDLLQRIDARGTTPWSATCFRYTGAHRDPLSGEGARRFGGRWNPPLLFSAIYLSDSAQACMVEVGRAAQAASTT
AEKLLEASYRLHTVEATDLAVLDLTTPEARDTVGLEDDDIHGEDWSACQAVGHAAWFLHMQGILVPAAGGVGLVITAYEQ
RTRPGQLQVSHSEDLTPARYQELRHK
VSDALDEDLLQRIDARGTTPWSATCFRYTGAHRDPLSGEGARRFGGRWNPPLLFSAIYLSDSAQACMVEVGRAAQAASTT
AEKLLEASYRLHTVEATDLAVLDLTTPEARDTVGLEDDDIHGEDWSACQAVGHAAWFLHMQGILVPAAGGVGLVITAYEQ
RTRPGQLQVSHSEDLTPARYQELRHK
Download Length: 561 bp
>T30574 NZ_AP012556:11085-11645 [Mycobacterium avium subsp. hominissuis TH135]
GTGAGCGATGCGCTCGACGAAGATCTGCTCCAGCGCATCGACGCGCGTGGAACCACCCCCTGGTCGGCGACATGCTTCCG
ATACACCGGTGCACATCGTGACCCTCTGTCGGGCGAGGGAGCTCGCCGATTCGGCGGCAGGTGGAATCCTCCCCTGCTGT
TCTCCGCGATCTACCTTTCCGACTCGGCCCAGGCGTGCATGGTCGAAGTAGGACGAGCAGCCCAGGCAGCGTCGACGACC
GCCGAGAAGCTGCTCGAAGCGAGCTACCGACTGCACACCGTCGAAGCGACCGACCTGGCTGTCCTGGATCTCACCACCCC
CGAGGCTCGCGACACGGTAGGGCTTGAAGATGACGACATCCACGGCGAGGACTGGTCGGCCTGCCAAGCAGTGGGCCACG
CCGCATGGTTTCTGCACATGCAAGGCATACTGGTGCCCGCAGCCGGCGGAGTCGGCCTCGTCATCACCGCCTACGAACAA
CGCACCCGACCCGGCCAGCTCCAGGTCAGCCACAGCGAGGATCTGACCCCCGCCCGCTACCAAGAACTACGGCACAAATG
A
GTGAGCGATGCGCTCGACGAAGATCTGCTCCAGCGCATCGACGCGCGTGGAACCACCCCCTGGTCGGCGACATGCTTCCG
ATACACCGGTGCACATCGTGACCCTCTGTCGGGCGAGGGAGCTCGCCGATTCGGCGGCAGGTGGAATCCTCCCCTGCTGT
TCTCCGCGATCTACCTTTCCGACTCGGCCCAGGCGTGCATGGTCGAAGTAGGACGAGCAGCCCAGGCAGCGTCGACGACC
GCCGAGAAGCTGCTCGAAGCGAGCTACCGACTGCACACCGTCGAAGCGACCGACCTGGCTGTCCTGGATCTCACCACCCC
CGAGGCTCGCGACACGGTAGGGCTTGAAGATGACGACATCCACGGCGAGGACTGGTCGGCCTGCCAAGCAGTGGGCCACG
CCGCATGGTTTCTGCACATGCAAGGCATACTGGTGCCCGCAGCCGGCGGAGTCGGCCTCGTCATCACCGCCTACGAACAA
CGCACCCGACCCGGCCAGCTCCAGGTCAGCCACAGCGAGGATCTGACCCCCGCCCGCTACCAAGAACTACGGCACAAATG
A
Antitoxin
Download Length: 114 a.a. Molecular weight: 12350.16 Da Isoelectric Point: 5.0916
>AT30574 WP_023870435.1 NZ_AP012556:10747-11088 [Mycobacterium avium subsp. hominissuis TH135]
MGVNALASTVSSAIERLGLTYEEVGGIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLQHAKPADLVRDGEYQRVLALIDAMAEGIFV
MGVNALASTVSSAIERLGLTYEEVGGIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLQHAKPADLVRDGEYQRVLALIDAMAEGIFV
Download Length: 342 bp
>AT30574 NZ_AP012556:10747-11088 [Mycobacterium avium subsp. hominissuis TH135]
ATGGGAGTTAACGCGCTCGCCTCGACGGTGTCCAGTGCGATCGAGCGCCTGGGATTGACCTACGAGGAGGTCGGCGGCAT
CGTCGATGCGTCTGCGCGCTCGGTGGCGCGCTGGACCTCAGGGCAGGTCGTCCCGCAACGCCTCAACAAGCAACGACTGA
TCGAGCTGGCCTACGTTGCCGACGCGCTGGCCGAAGTCCTTCCCCGTGACCAGGCCAACGTGTGGATGTTCTCGCCGAAT
CGACTACTGCAGCACGCCAAACCTGCCGACCTGGTACGCGACGGTGAGTATCAGCGCGTCTTGGCGCTGATTGACGCGAT
GGCCGAAGGGATCTTCGTGTGA
ATGGGAGTTAACGCGCTCGCCTCGACGGTGTCCAGTGCGATCGAGCGCCTGGGATTGACCTACGAGGAGGTCGGCGGCAT
CGTCGATGCGTCTGCGCGCTCGGTGGCGCGCTGGACCTCAGGGCAGGTCGTCCCGCAACGCCTCAACAAGCAACGACTGA
TCGAGCTGGCCTACGTTGCCGACGCGCTGGCCGAAGTCCTTCCCCGTGACCAGGCCAACGTGTGGATGTTCTCGCCGAAT
CGACTACTGCAGCACGCCAAACCTGCCGACCTGGTACGCGACGGTGAGTATCAGCGCGTCTTGGCGCTGATTGACGCGAT
GGCCGAAGGGATCTTCGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A859PX34 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A859PYE6 |