Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/ParD(antitoxin)
Location 2898935..2899933 Replicon chromosome
Accession NZ_AP012555
Organism Mycobacterium avium subsp. hominissuis TH135

Toxin (Protein)


Gene name pezT Uniprot ID X7VT18
Locus tag MAH_RS13080 Protein ID WP_003876749.1
Coordinates 2898935..2899513 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A049EEK5
Locus tag MAH_RS13085 Protein ID WP_009976725.1
Coordinates 2899544..2899933 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAH_RS13055 2894927..2895859 - 933 WP_023869126.1 sigma-70 family RNA polymerase sigma factor -
MAH_RS13060 2896028..2896378 + 351 WP_003878038.1 DoxX family protein -
MAH_RS13065 2896392..2897192 - 801 WP_031354074.1 nuclear transport factor 2 family protein -
MAH_RS13070 2897192..2897752 - 561 WP_155251422.1 pyrazinamidase PncA -
MAH_RS13075 2897863..2898930 + 1068 WP_023869125.1 DoxX family membrane protein -
MAH_RS13080 2898935..2899513 - 579 WP_003876749.1 zeta toxin family protein Toxin
MAH_RS13085 2899544..2899933 - 390 WP_009976725.1 hypothetical protein Antitoxin
MAH_RS13090 2900014..2900508 - 495 WP_023869124.1 gluconokinase -
MAH_RS13095 2900505..2902502 - 1998 WP_023869123.1 phosphotransferase -
MAH_RS13100 2902521..2904038 - 1518 WP_011724808.1 carboxylesterase/lipase family protein -
MAH_RS13105 2904118..2904798 + 681 WP_023869122.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(5-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21034.18 Da        Isoelectric Point: 10.6678

>T30573 WP_003876749.1 NZ_AP012555:c2899513-2898935 [Mycobacterium avium subsp. hominissuis TH135]
MERLDVVVGPNGAGKSTFIALTLAPLLPGSVVVNADEIARQRWPQDPASHAYDAAKVAADTRAKLIDLGRSFIAETVFSH
PSKLDLLHAARRAGFTVVLHVLLIPEDLAVERVRHRVRAGGHDVPETKIRERHRRLWTPVAEAMTLADLATGYDNSRLRG
PRVVARLSGGLTVGAVDWPAWAPETLRSRWPV

Download         Length: 579 bp

>T30573 NZ_AP012555:c2899513-2898935 [Mycobacterium avium subsp. hominissuis TH135]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCATGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTCGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13598.04 Da        Isoelectric Point: 5.6717

>AT30573 WP_009976725.1 NZ_AP012555:c2899933-2899544 [Mycobacterium avium subsp. hominissuis TH135]
MAEAVDRVTRVASDLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHTASRRRVEAALAGRLSTAELTVEEGVVFNAEI
SAAIDESLARTNYGATLAGQGVTTVALNDDGEIVEHRPDGTAVVLAGRR

Download         Length: 390 bp

>AT30573 NZ_AP012555:c2899933-2899544 [Mycobacterium avium subsp. hominissuis TH135]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGACCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGACGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E2W6B4

Antitoxin

Source ID Structure
AlphaFold DB A0A049EEK5

References