Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3068193..3068854 Replicon chromosome
Accession NZ_AP012547
Organism Sulfuritalea hydrogenivorans sk43H strain DSM 22779

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SUTH_RS14690 Protein ID WP_197539732.1
Coordinates 3068193..3068603 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SUTH_RS14695 Protein ID WP_197539733.1
Coordinates 3068618..3068854 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SUTH_RS14670 3063394..3064236 - 843 WP_197539596.1 hypothetical protein -
SUTH_RS14675 3064405..3064614 - 210 WP_041100294.1 BrnA antitoxin family protein -
SUTH_RS14680 3064921..3065892 - 972 WP_041097738.1 IS5 family transposase -
SUTH_RS18650 3066033..3067184 - 1152 WP_084207434.1 DUF4236 domain-containing protein -
SUTH_RS19135 3067874..3068069 + 196 Protein_2930 transposase -
SUTH_RS14690 3068193..3068603 - 411 WP_197539732.1 type II toxin-antitoxin system VapC family toxin Toxin
SUTH_RS14695 3068618..3068854 - 237 WP_197539733.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
SUTH_RS14700 3068984..3069496 - 513 WP_041100300.1 formate hydrogenlyase -
SUTH_RS14705 3069652..3071226 - 1575 WP_041100302.1 NADH-quinone oxidoreductase subunit C -
SUTH_RS14710 3071229..3072680 - 1452 WP_041100304.1 hydrogenase 4 subunit F -
SUTH_RS14715 3072680..3073348 - 669 WP_041100306.1 formate hydrogenlyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3064921..3065892 971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(9-48)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14549.49 Da        Isoelectric Point: 4.9145

>T30569 WP_197539732.1 NZ_AP012547:c3068603-3068193 [Sulfuritalea hydrogenivorans sk43H]
MLDTNILSDLIRYPRGAAARRLAEVGVDAICTSIVVACELRYGAARRDSAPLTQRVEALLSSLSVLPFEADADSHYADIR
ATLERAGAPIGGNDLLIAAHGRSLGATVVTHNLREFERVPGLRVEDWLAGDPDIAS

Download         Length: 411 bp

>T30569 NZ_AP012547:c3068603-3068193 [Sulfuritalea hydrogenivorans sk43H]
CTGCTCGACACCAATATCCTTTCCGACCTGATCCGGTATCCGCGCGGCGCGGCGGCGCGGCGCCTGGCGGAGGTCGGTGT
CGATGCGATTTGCACCAGCATCGTGGTGGCCTGCGAACTCCGCTATGGCGCGGCACGGCGCGACTCGGCACCGCTCACGC
AGCGGGTGGAGGCGCTGCTTTCCAGTCTGTCGGTGCTGCCTTTCGAGGCCGATGCCGACAGCCACTACGCCGACATTCGC
GCCACGCTGGAGCGCGCTGGAGCGCCCATCGGCGGCAACGACCTGCTGATCGCCGCCCACGGCCGCTCACTGGGCGCCAC
CGTCGTCACCCACAACCTGCGCGAGTTCGAGCGTGTGCCAGGTTTGCGGGTGGAGGACTGGCTGGCGGGCGATCCCGACA
TAGCAAGCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8895.14 Da        Isoelectric Point: 4.5173

>AT30569 WP_197539733.1 NZ_AP012547:c3068854-3068618 [Sulfuritalea hydrogenivorans sk43H]
INERHVSLFRNGRNQAIRIPREFELAGTEAIIRKEGERLIIEPAPPRERLLTLLAGWEPLDEAFPEIPDTPTAPEDVL

Download         Length: 237 bp

>AT30569 NZ_AP012547:c3068854-3068618 [Sulfuritalea hydrogenivorans sk43H]
ATCAACGAGCGCCATGTTTCCCTGTTTCGCAACGGTCGCAACCAGGCGATCCGGATCCCCCGCGAATTCGAGCTCGCGGG
TACCGAGGCCATCATCCGCAAGGAAGGCGAGCGGCTGATCATCGAGCCGGCACCGCCGCGCGAGCGGCTGCTGACGCTGC
TGGCCGGATGGGAGCCGCTGGATGAGGCGTTTCCTGAAATCCCCGATACACCGACGGCGCCCGAGGACGTGCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References