Detailed information of TA system TA030567

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1845114..1845704
• Replicon: chromosome
• Accession: NZ_AP012547
• Organism: Sulfuritalea hydrogenivorans sk43H strain DSM 22779

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SUTH_RS09025
• Protein ID: WP_197539669.1
• Coordinates: 1845540..1845704 (-)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: W0SF67
• Locus tag: SUTH_RS09020
• Protein ID: WP_041098706.1
• Coordinates: 1845114..1845530 (-)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUTH_RS09005	1840429..1841388	+	960	WP_041098702.1	hypothetical protein	-
SUTH_RS09010	1842006..1842806	+	801	WP_084207313.1	Crp/Fnr family transcriptional regulator	-
SUTH_RS09015	1842915..1845107	+	2193	WP_052473467.1	type I secretion system permease/ATPase	-
SUTH_RS09020	1845114..1845530	-	417	WP_041098706.1	helix-turn-helix domain-containing protein	Antitoxin
SUTH_RS09025	1845540..1845704	-	165	WP_197539669.1	type II toxin-antitoxin system HicA family toxin	Toxin
SUTH_RS09030	1845767..1847224	+	1458	WP_041098710.1	HlyD family type I secretion periplasmic adaptor subunit	-
SUTH_RS09035	1847352..1848014	+	663	WP_041098712.1	hypothetical protein	-
SUTH_RS19335	1848027..1849835	+	1809	Protein_1799	hypothetical protein	-
SUTH_RS19345	1850355..1850594	+	240	Protein_1800	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (2-53)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-62)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 5988.11 Da
• Isoelectric Point: 11.1711

>T30567 WP_197539669.1 NZ_AP012547:c1845704-1845540 [Sulfuritalea hydrogenivorans sk43H]
MKKWLEQQGATFLPAKGSHLKVFLNGRQTILPMHGTTELGKGLEASIKRQLGLK

Nucleotide

• Length: 165 bp

>T30567 NZ_AP012547:c1845704-1845540 [Sulfuritalea hydrogenivorans sk43H]
ATGAAGAAATGGCTGGAACAACAGGGCGCCACTTTCCTGCCGGCCAAAGGGTCTCATCTGAAGGTTTTTCTGAACGGCCG
GCAAACCATCCTGCCCATGCACGGCACTACGGAACTCGGCAAGGGCCTTGAGGCGTCGATCAAACGCCAGCTTGGATTGA
AGTGA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15282.47 Da
• Isoelectric Point: 6.0912

>AT30567 WP_041098706.1 NZ_AP012547:c1845530-1845114 [Sulfuritalea hydrogenivorans sk43H]
MFDYPVILAPDEGTVLVTFPDVPEAITFGADTDEALLQAVDALESALSFYVDDRKPLPTPSKPKRGQHTVRPSALECAKL
GVYRAMTEQGIKKSELARRLGWHMPQVDRLFDLRHASRLDQIEAAARALGRHVEVSVS

Nucleotide

• Length: 417 bp

>AT30567 NZ_AP012547:c1845530-1845114 [Sulfuritalea hydrogenivorans sk43H]
ATGTTTGACTACCCTGTTATTCTGGCTCCCGACGAAGGCACGGTGTTGGTGACCTTTCCGGATGTGCCGGAGGCCATTAC
ATTTGGCGCGGACACCGACGAGGCGCTGCTTCAGGCCGTCGATGCGCTTGAATCCGCGCTTTCGTTCTACGTCGATGACC
GCAAACCCTTGCCGACTCCGAGCAAACCAAAACGCGGGCAGCATACGGTGCGCCCTTCCGCCTTGGAGTGCGCCAAGCTG
GGCGTCTATCGGGCCATGACCGAGCAGGGCATCAAGAAGTCCGAACTGGCCCGCCGCCTGGGCTGGCACATGCCGCAGGT
GGATCGGCTGTTCGATCTGCGGCATGCGTCGCGACTCGACCAGATCGAAGCGGCGGCGCGGGCACTGGGGCGGCATGTCG
AGGTGTCGGTCTCGTAA

Structures

Antitoxin

• AlphaFold DB: W0SF67