Detailed information of TA system TA030566

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1550293..1550625
• Replicon: chromosome
• Accession: NZ_AP012547
• Organism: Sulfuritalea hydrogenivorans sk43H strain DSM 22779

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SUTH_RS19865
• Protein ID: WP_197539665.1
• Coordinates: 1550506..1550625 (+)
• Length: 40 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SUTH_RS18995
• Protein ID: WP_084207297.1
• Coordinates: 1550293..1550502 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUTH_RS07515	1546645..1547025	-	381	WP_041098309.1	Mth938-like domain-containing protein	-
SUTH_RS07520	1547191..1548417	+	1227	WP_041101949.1	pyridoxal phosphate-dependent aminotransferase	-
SUTH_RS07525	1548407..1548859	+	453	WP_041098311.1	GNAT family N-acetyltransferase	-
SUTH_RS07530	1548856..1550166	+	1311	WP_041098312.1	homoserine dehydrogenase	-
SUTH_RS18995	1550293..1550502	+	210	WP_084207297.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SUTH_RS19865	1550506..1550625	+	120	WP_197539665.1	type II toxin-antitoxin system HicA family toxin	Toxin
SUTH_RS07540	1550767..1551267	+	501	WP_084207298.1	hypothetical protein	-
SUTH_RS07545	1551387..1552811	+	1425	WP_041098315.1	threonine synthase	-
SUTH_RS19620	1552869..1553006	-	138	WP_171817332.1	hypothetical protein	-
SUTH_RS07550	1553086..1555464	-	2379	WP_041101951.1	DNA topoisomerase IV subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (11-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 40 a.a.
• Molecular weight: 4414.16 Da
• Isoelectric Point: 11.9644

>T30566 WP_197539665.1 NZ_AP012547:1550506-1550625 [Sulfuritalea hydrogenivorans sk43H]
MGNVPVLKPHEVIAILVRLGFTEVRQRGSHKQFRDTAGR

Nucleotide

• Length: 120 bp

>T30566 NZ_AP012547:1550506-1550625 [Sulfuritalea hydrogenivorans sk43H]
ATGGGAAATGTTCCGGTCCTCAAACCCCATGAAGTCATTGCCATTCTTGTCAGGCTCGGATTTACTGAAGTCCGCCAACG
CGGCTCGCACAAACAATTCCGCGATACCGCTGGCCGCTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 7457.45 Da
• Isoelectric Point: 4.0818

>AT30566 WP_084207297.1 NZ_AP012547:1550293-1550502 [Sulfuritalea hydrogenivorans sk43H]
MRVYSAVIERCAQTGLFVGFVPGFPGAHSQGETLDELNHNLHDVIAMLLEDGEPMLESEFVGVQNVAVA

Nucleotide

• Length: 210 bp

>AT30566 NZ_AP012547:1550293-1550502 [Sulfuritalea hydrogenivorans sk43H]
ATGAGAGTCTATTCAGCGGTAATTGAACGGTGCGCACAAACCGGCCTGTTCGTTGGTTTCGTTCCCGGCTTTCCTGGCGC
GCATTCCCAGGGCGAAACGCTGGATGAACTCAACCACAACCTGCACGACGTAATTGCAATGCTTCTGGAGGATGGCGAAC
CCATGCTGGAGTCGGAGTTTGTCGGGGTTCAAAACGTTGCCGTAGCTTGA