Detailed information of TA system TA030565

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1285373..1286049
• Replicon: chromosome
• Accession: NZ_AP012547
• Organism: Sulfuritalea hydrogenivorans sk43H strain DSM 22779

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: W0SCV7
• Locus tag: SUTH_RS06210
• Protein ID: WP_041097936.1
• Coordinates: 1285621..1286049 (+)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: W0SH47
• Locus tag: SUTH_RS06205
• Protein ID: WP_041097934.1
• Coordinates: 1285373..1285621 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SUTH_RS06180	1280572..1281531	+	960	WP_041097928.1	Gfo/Idh/MocA family oxidoreductase	-
SUTH_RS06185	1281885..1282886	+	1002	WP_041097929.1	aldo/keto reductase	-
SUTH_RS06190	1282897..1283253	+	357	WP_041097930.1	protocatechuate 4,5-dioxygenase subunit alpha	-
SUTH_RS06195	1283256..1284095	+	840	WP_041097931.1	protocatechuate 3,4-dioxygenase	-
SUTH_RS06200	1284115..1285287	+	1173	WP_041097932.1	4-hydroxybenzoate 3-monooxygenase	-
SUTH_RS06205	1285373..1285621	+	249	WP_041097934.1	ribbon-helix-helix domain-containing protein	Antitoxin
SUTH_RS06210	1285621..1286049	+	429	WP_041097936.1	PIN domain-containing protein	Toxin
SUTH_RS06215	1286160..1287113	-	954	WP_197539653.1	AEC family transporter	-
SUTH_RS06220	1287425..1288684	-	1260	WP_171817323.1	hypothetical protein	-
SUTH_RS06225	1289043..1290014	-	972	WP_041096297.1	IS5 family transposase	-
SUTH_RS06230	1290090..1290482	-	393	WP_041097939.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1289043..1290014	971

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15252.82 Da
• Isoelectric Point: 9.8250

>T30565 WP_041097936.1 NZ_AP012547:1285621-1286049 [Sulfuritalea hydrogenivorans sk43H]
MRALLDVNVLIALLDSDHLHHARARAWLKENIKAGWASCPLTQNGCIRIMAQPGYPNALPAAAVAERLTAATATTHHAFW
PDAVSMLDAGRITWNAVLGARQVTDVYLLALAVEQGGRLVTLDRAVPLKAVPGAKARHLVVI

Nucleotide

• Length: 429 bp

>T30565 NZ_AP012547:1285621-1286049 [Sulfuritalea hydrogenivorans sk43H]
ATGCGCGCCTTGCTCGACGTCAATGTGCTGATCGCCCTGCTCGACAGCGATCATCTGCATCACGCGCGCGCCAGGGCGTG
GCTGAAGGAGAACATCAAGGCCGGCTGGGCGTCCTGCCCGCTGACGCAGAACGGCTGCATCCGCATCATGGCGCAACCCG
GCTATCCCAACGCGTTGCCAGCGGCGGCGGTGGCGGAACGCCTGACCGCCGCGACGGCGACCACGCATCACGCCTTCTGG
CCGGACGCCGTCAGCATGCTCGATGCCGGACGCATTACCTGGAACGCCGTGCTCGGCGCCCGCCAGGTGACGGATGTCTA
TCTGCTGGCGCTGGCGGTGGAGCAGGGCGGACGGCTGGTCACGCTGGATCGGGCGGTGCCGCTGAAGGCGGTACCCGGTG
CCAAAGCCCGGCATCTTGTGGTGATCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8809.79 Da
• Isoelectric Point: 5.8064

>AT30565 WP_041097934.1 NZ_AP012547:1285373-1285621 [Sulfuritalea hydrogenivorans sk43H]
MRTTLEIDDDVLHAAKELSRRGGTTAGRVISDLVRQALTQPAASTANGVREPAAVYGFRPFPSRGSVVTNDQVDKLRDEE
GA

Nucleotide

• Length: 249 bp

>AT30565 NZ_AP012547:1285373-1285621 [Sulfuritalea hydrogenivorans sk43H]
ATGCGAACCACGCTCGAAATCGACGACGATGTTCTGCATGCCGCCAAGGAGCTTTCCCGTCGCGGCGGGACAACGGCCGG
GCGGGTGATTTCCGACCTGGTGCGGCAGGCGCTGACGCAACCGGCGGCAAGCACGGCCAATGGCGTCAGGGAACCGGCGG
CGGTGTATGGCTTTCGCCCGTTTCCGTCGCGCGGCAGCGTGGTCACCAACGATCAGGTCGACAAGCTGCGCGACGAAGAA
GGCGCCTGA

Structures

Toxin

• AlphaFold DB: W0SCV7

Antitoxin

• AlphaFold DB: W0SH47