Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1235034..1235590 Replicon chromosome
Accession NZ_AP012547
Organism Sulfuritalea hydrogenivorans sk43H strain DSM 22779

Toxin (Protein)


Gene name ccdB Uniprot ID W0SDZ6
Locus tag SUTH_RS05940 Protein ID WP_041097833.1
Coordinates 1235034..1235348 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W0SD66
Locus tag SUTH_RS05945 Protein ID WP_041097835.1
Coordinates 1235348..1235590 (-) Length 81 a.a.

Genomic Context


SUTH_RS05920SUTH_RS18330SUTH_RS05925SUTH_RS05930SUTH_RS05935SUTH_RS05940SUTH_RS05945SUTH_RS05955SUTH_RS05960SUTH_RS05965SUTH_RS05970SUTH_RS05975SUTH_RS05980
Location: 1231671..1232216 (546 bp)
Type: Others
Protein ID: WP_041097827.1
Location: 1235702..1236652 (951 bp)
Type: Others
Protein ID: WP_052473317.1
Location: 1232161..1233075 (915 bp)
Type: Others
Protein ID: WP_084207274.1
Location: 1233089..1233349 (261 bp)
Type: Others
Protein ID: WP_041097829.1
Location: 1233353..1235017 (1665 bp)
Type: Others
Protein ID: WP_041097831.1
Location: 1235034..1235348 (315 bp)
Type: Toxin
Protein ID: WP_041097833.1
Location: 1235348..1235590 (243 bp)
Type: Antitoxin
Protein ID: WP_041097835.1
Location: 1236653..1236922 (270 bp)
Type: Others
Protein ID: WP_041097837.1
Location: 1236931..1238376 (1446 bp)
Type: Others
Protein ID: WP_084207275.1
Location: 1238271..1238954 (684 bp)
Type: Others
Protein ID: WP_041097841.1
Location: 1239189..1239713 (525 bp)
Type: Others
Protein ID: WP_041097843.1
Location: 1239753..1240133 (381 bp)
Type: Others
Protein ID: WP_041097845.1
Location: 1240133..1240345 (213 bp)
Type: Others
Protein ID: WP_041097847.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SUTH_RS059201231671..1232216+546WP_041097827.1ubiquinol-cytochrome c reductase iron-sulfur subunit-
SUTH_RS059251232161..1233075-915WP_084207274.1DMT family transporter-
SUTH_RS059301233089..1233349-261WP_041097829.1hypothetical protein-
SUTH_RS059351233353..1235017-1665WP_041097831.1energy-dependent translational throttle protein EttA-
SUTH_RS059401235034..1235348-315WP_041097833.1CcdB family proteinToxin
SUTH_RS059451235348..1235590-243WP_041097835.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
SUTH_RS183301235702..1236652+951WP_052473317.1hypothetical protein-
SUTH_RS059551236653..1236922-270WP_041097837.1biotin/lipoyl-binding protein-
SUTH_RS059601236931..1238376-1446WP_084207275.1tRNA 5-hydroxyuridine modification protein YegQ-
SUTH_RS059651238271..1238954-684WP_041097841.1glutathione S-transferase family protein-
SUTH_RS059701239189..1239713-525WP_041097843.1glycine cleavage system protein R-
SUTH_RS059751239753..1240133-381WP_041097845.1type II toxin-antitoxin system VapC family toxin-
SUTH_RS059801240133..1240345-213WP_041097847.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-103)

Antitoxin

(6-76)


Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11316.08 Da        Isoelectric Point: 4.4667

>T30564 WP_041097833.1 NZ_AP012547:c1235348-1235034 [Sulfuritalea hydrogenivorans sk43H]
MAHLDVFRNPDATTASVIPYVVDVQSELLADLPTHVVIPLAYPEAIETPILRLNPKVGVGDTALVVLTQDMASVSNRLLR
HPVANLSPQRDEILAALDFLFTGF

Download         Length: 315 bp

>T30564 NZ_AP012547:c1235348-1235034 [Sulfuritalea hydrogenivorans sk43H]
ATGGCTCACCTCGACGTCTTTCGCAATCCGGATGCCACGACGGCAAGCGTCATCCCCTACGTAGTCGACGTCCAGAGCGA
ACTGCTCGCTGACCTGCCTACCCACGTCGTCATCCCCTTGGCCTATCCTGAAGCCATCGAGACCCCGATCCTGCGCCTCA
ACCCGAAAGTCGGCGTCGGCGACACGGCGTTGGTCGTATTGACACAGGACATGGCCTCGGTGTCAAACCGCCTGCTGCGA
CACCCCGTTGCCAACCTTTCCCCCCAGCGCGACGAGATCCTTGCCGCGCTGGATTTCCTTTTCACCGGTTTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9234.59 Da        Isoelectric Point: 9.8330

>AT30564 WP_041097835.1 NZ_AP012547:c1235590-1235348 [Sulfuritalea hydrogenivorans sk43H]
MSAHPKKAANLTVRADLLEEARARKINLSQTLEVALSVELKKCRETEWLEQNKEAIAAYGRFVEKHGVFSDRFRNFMREG

Download         Length: 243 bp

>AT30564 NZ_AP012547:c1235590-1235348 [Sulfuritalea hydrogenivorans sk43H]
ATGAGCGCCCATCCCAAGAAAGCCGCCAACCTCACCGTCCGCGCCGATCTGCTTGAAGAAGCCCGCGCGCGCAAGATCAA
CCTCTCGCAGACGCTCGAAGTCGCGCTTTCCGTCGAGCTGAAGAAGTGTCGCGAAACCGAGTGGCTGGAGCAGAACAAGG
AGGCCATTGCCGCCTACGGGCGTTTCGTCGAGAAGCACGGCGTGTTCTCCGACCGCTTCCGCAACTTCATGCGTGAGGGT
TGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBW0SDZ6


Antitoxin

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Source
ID
Structure
AlphaFold DBW0SD66

References